# Me LLaMA: Foundation Large Language Models for Medical Applications

arXiv: https://arxiv.org/abs/2402.12749 · HTML: https://mlsanity.com/paper/2402.12749/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Builds on 24 of its 42 references that are in the map.
- First posted on arXiv 20 Feb 2024.

## Builds on (most cited first, 24 of 24)

- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [Learning to summarize from human feedback](https://mlsanity.com/paper/2009.01325/) (2020)
- [The Pile: An 800GB Dataset of Diverse Text for Language Modeling](https://mlsanity.com/paper/2101.00027/) (2020)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [A Discourse-Aware Attention Model for Abstractive Summarization of Long Documents](https://mlsanity.com/paper/1804.05685/) (2018)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [LongLoRA: Efficient Fine-tuning of Long-Context Large Language Models](https://mlsanity.com/paper/2309.12307/) (2023)
- [A Study of Generative Large Language Model for Medical Research and Healthcare](https://mlsanity.com/paper/2305.13523/) (2023)
- [Lessons from Natural Language Inference in the Clinical Domain](https://mlsanity.com/paper/1808.06752/) (2018)
- [emrQA: A Large Corpus for Question Answering on Electronic Medical Records](https://mlsanity.com/paper/1809.00732/) (2018)
- [Towards Accurate Differential Diagnosis with Large Language Models](https://mlsanity.com/paper/2312.00164/) (2023)
- [AlpaCare:Instruction-tuned Large Language Models for Medical Application](https://mlsanity.com/paper/2310.14558/) (2023)
- [Diagnostic Reasoning Prompts Reveal the Potential for Large Language Model Interpretability in Medicine](https://mlsanity.com/paper/2308.06834/) (2023)
- [Parameter-Efficient Fine-Tuning of LLaMA for the Clinical Domain](https://mlsanity.com/paper/2307.03042/) (2023)
- [Medical Exam Question Answering with Large-scale Reading Comprehension](https://mlsanity.com/paper/1802.10279/) (2018)
- [BioNLI: Generating a Biomedical NLI Dataset Using Lexico-semantic Constraints for Adversarial Examples](https://mlsanity.com/paper/2210.14814/) (2022)

## Built on by (most cited first, 10 of 10)

- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [Small Language Models Learn Enhanced Reasoning Skills from Medical Textbooks](https://mlsanity.com/paper/2404.00376/) (2024)
- [ColaCare: Enhancing Electronic Health Record Modeling through Large Language Model-Driven Multi-Agent Collaboration](https://mlsanity.com/paper/2410.02551/) (2024)
- [Towards Adapting Open-Source Large Language Models for Expert-Level Clinical Note Generation](https://mlsanity.com/paper/2405.00715/) (2024)
- [LLMs are not Zero-Shot Reasoners for Biomedical Information Extraction](https://mlsanity.com/paper/2408.12249/) (2024)
- [HaLoRA: Hardware-aware Low-Rank Adaptation for Large Language Models Based on Hybrid Compute-in-Memory Architecture](https://mlsanity.com/paper/2502.19747/) (2025)
- [Technical Report: Small Language Model for Japanese Clinical and Medicine](https://mlsanity.com/paper/2412.16423/) (2024)
- [Clinically Grounded Privacy Evaluation of Medical LMs](https://mlsanity.com/paper/2606.09590/) (2026)
- [LLM Evolution as an Industry-Scale Ecosystem: A Lifecycle Perspective on Continual Learning](https://mlsanity.com/paper/2606.24901/) (2026)

## Abstract (arXiv)

Recent advancements in large language models (LLMs) like ChatGPT and LLaMA show promise in medical applications, yet challenges remain in medical language comprehension. This study presents Me-LLaMA, a new medical LLM family based on open-source LLaMA models, optimized for medical text analysis and diagnosis by leveraging large-scale, domain-specific datasets. The Me-LLaMA family, including foundation models Me-LLaMA 13/70B and their chat-enhanced versions, was developed through continued pre-training and instruction tuning with 129B tokens and 214K samples from biomedical and clinical sources. Training the 70B models required over 100,000 A100 GPU hours. Me-LLaMA's performance was evaluated across six medical text analysis tasks using 12 benchmark datasets and complex clinical case diagnosis, with automatic and human evaluations. Results indicate Me-LLaMA outperforms LLaMA and other open-source medical LLMs in zero-shot and supervised settings. Task-specific tuning further boosts performance, surpassing ChatGPT on 7 of 8 datasets and GPT-4 on 5 of 8. For complex clinical cases, Me-LLaMA achieves performance comparable to ChatGPT and GPT-4. This work underscores the importance of domain-specific data in developing medical LLMs and addresses the high computational costs involved in training, highlighting a balance between pre-training and fine-tuning strategies. Me-LLaMA models are now accessible under user agreements, providing a valuable resource for advancing medical AI.