# BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains

arXiv: https://arxiv.org/abs/2402.10373 · HTML: https://mlsanity.com/paper/2402.10373/

## Key facts

- Cited by 301 papers in the map (data through 14 Oct 2026).
- Builds on 43 of its 69 references that are in the map.
- First posted on arXiv 15 Feb 2024.

## Builds on (most cited first, 30 of 43)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Longformer: The Long-Document Transformer](https://mlsanity.com/paper/2004.05150/) (2020)
- [TruthfulQA: Measuring How Models Mimic Human Falsehoods](https://mlsanity.com/paper/2109.07958/) (2021)
- [FlashAttention-2: Faster Attention with Better Parallelism and Work Partitioning](https://mlsanity.com/paper/2307.08691/) (2023)
- [SentencePiece: A simple and language independent subword tokenizer and detokenizer for Neural Text Processing](https://mlsanity.com/paper/1808.06226/) (2018)
- [BLOOM: A 176B-Parameter Open-Access Multilingual Language Model](https://mlsanity.com/paper/2211.05100/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Model soups: averaging weights of multiple fine-tuned models improves accuracy without increasing inference time](https://mlsanity.com/paper/2203.05482/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [GQA: Training Generalized Multi-Query Transformer Models from Multi-Head Checkpoints](https://mlsanity.com/paper/2305.13245/) (2023)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [GPT-NeoX-20B: An Open-Source Autoregressive Language Model](https://mlsanity.com/paper/2204.06745/) (2022)
- [Language Models are Super Mario: Absorbing Abilities from Homologous Models as a Free Lunch](https://mlsanity.com/paper/2311.03099/) (2023)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [The Falcon Series of Open Language Models](https://mlsanity.com/paper/2311.16867/) (2023)
- [Zephyr: Direct Distillation of LM Alignment](https://mlsanity.com/paper/2310.16944/) (2023)
- [Git Re-Basin: Merging Models modulo Permutation Symmetries](https://mlsanity.com/paper/2209.04836/) (2022)
- [SWAD: Domain Generalization by Seeking Flat Minima](https://mlsanity.com/paper/2102.08604/) (2021)
- [BOLD: Dataset and Metrics for Measuring Biases in Open-Ended Language Generation](https://mlsanity.com/paper/2101.11718/) (2021)
- [Dataless Knowledge Fusion by Merging Weights of Language Models](https://mlsanity.com/paper/2212.09849/) (2022)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)

## Built on by (most cited first, 30 of 301)

- [HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs](https://mlsanity.com/paper/2412.18925/) (2024)
- [Arcee's MergeKit: A Toolkit for Merging Large Language Models](https://mlsanity.com/paper/2403.13257/) (2024)
- [MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs](https://mlsanity.com/paper/2504.00993/) (2025)
- [On-Device Language Models: A Comprehensive Review](https://mlsanity.com/paper/2409.00088/) (2024)
- [A Review of Large Language Models and Autonomous Agents in Chemistry](https://mlsanity.com/paper/2407.01603/) (2024)
- [A Comprehensive Survey of Scientific Large Language Models and Their Applications in Scientific Discovery](https://mlsanity.com/paper/2406.10833/) (2024)
- [Towards Building Multilingual Language Model for Medicine](https://mlsanity.com/paper/2402.13963/) (2024)
- [Advancing Multimodal Medical Capabilities of Gemini](https://mlsanity.com/paper/2405.03162/) (2024)
- [Reuse, Don't Retrain: A Recipe for Continued Pretraining of Language Models](https://mlsanity.com/paper/2407.07263/) (2024)
- [UltraMedical: Building Specialized Generalists in Biomedicine](https://mlsanity.com/paper/2406.03949/) (2024)
- [TensorOpera Router: A Multi-Model Router for Efficient LLM Inference](https://mlsanity.com/paper/2408.12320/) (2024)
- [SoK: Membership Inference Attacks on LLMs are Rushing Nowhere (and How to Fix It)](https://mlsanity.com/paper/2406.17975/) (2024)
- [Pack of LLMs: Model Fusion at Test-Time via Perplexity Optimization](https://mlsanity.com/paper/2404.11531/) (2024)
- [A Comprehensive Survey of Foundation Models in Medicine](https://mlsanity.com/paper/2406.10729/) (2024)
- [DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer's Disease Questions with Scientific Literature](https://mlsanity.com/paper/2405.04819/) (2024)
- [A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine](https://mlsanity.com/paper/2405.08603/) (2024)
- [WARP: On the Benefits of Weight Averaged Rewarded Policies](https://mlsanity.com/paper/2406.16768/) (2024)
- [MedExpQA: Multilingual Benchmarking of Large Language Models for Medical Question Answering](https://mlsanity.com/paper/2404.05590/) (2024)
- [BioRAG: A RAG-LLM Framework for Biological Question Reasoning](https://mlsanity.com/paper/2408.01107/) (2024)
- [SciRIFF: A Resource to Enhance Language Model Instruction-Following over Scientific Literature](https://mlsanity.com/paper/2406.07835/) (2024)
- [Rationale-Guided Retrieval Augmented Generation for Medical Question Answering](https://mlsanity.com/paper/2411.00300/) (2024)
- [TelecomGPT: A Framework to Build Telecom-Specfic Large Language Models](https://mlsanity.com/paper/2407.09424/) (2024)
- [Towards Evaluating and Building Versatile Large Language Models for Medicine](https://mlsanity.com/paper/2408.12547/) (2024)
- [Apollo: A Lightweight Multilingual Medical LLM towards Democratizing Medical AI to 6B People](https://mlsanity.com/paper/2403.03640/) (2024)
- [BMRetriever: Tuning Large Language Models as Better Biomedical Text Retrievers](https://mlsanity.com/paper/2404.18443/) (2024)
- [MedAdapter: Efficient Test-Time Adaptation of Large Language Models towards Medical Reasoning](https://mlsanity.com/paper/2405.03000/) (2024)
- [Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL](https://mlsanity.com/paper/2505.17952/) (2025)
- [MedHallu: A Comprehensive Benchmark for Detecting Medical Hallucinations in Large Language Models](https://mlsanity.com/paper/2502.14302/) (2025)
- [Scientists' First Exam: Probing Cognitive Abilities of MLLM via Perception, Understanding, and Reasoning](https://mlsanity.com/paper/2506.10521/) (2025)
- [JMLR: Joint Medical LLM and Retrieval Training for Enhancing Reasoning and Professional Question Answering Capability](https://mlsanity.com/paper/2402.17887/) (2024)

## Abstract (arXiv)

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored for health contexts, adapting general-purpose LLMs to the medical domain presents significant challenges. In this paper, we introduce BioMistral, an open-source LLM tailored for the biomedical domain, utilizing Mistral as its foundation model and further pre-trained on PubMed Central. We conduct a comprehensive evaluation of BioMistral on a benchmark comprising 10 established medical question-answering (QA) tasks in English. We also explore lightweight models obtained through quantization and model merging approaches. Our results demonstrate BioMistral's superior performance compared to existing open-source medical models and its competitive edge against proprietary counterparts. Finally, to address the limited availability of data beyond English and to assess the multilingual generalization of medical LLMs, we automatically translated and evaluated this benchmark into 7 other languages. This marks the first large-scale multilingual evaluation of LLMs in the medical domain. Datasets, multilingual evaluation benchmarks, scripts, and all the models obtained during our experiments are freely released.