# Boundary-aware Contrastive Learning for Semi-supervised Nuclei Instance Segmentation

arXiv: https://arxiv.org/abs/2402.04756 · HTML: https://mlsanity.com/paper/2402.04756/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 23 references that are in the map.
- First posted on arXiv 7 Feb 2024.

## Builds on (most cited first, 11 of 11)

- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Pixel Contrastive-Consistent Semi-Supervised Semantic Segmentation](https://mlsanity.com/paper/2108.09025/) (2021)
- [DCAN: Deep Contour-Aware Networks for Accurate Gland Segmentation](https://mlsanity.com/paper/1604.02677/) (2016)
- [Methods for Segmentation and Classification of Digital Microscopy Tissue Images](https://mlsanity.com/paper/1810.13230/) (2018)
- [CryoNuSeg: A Dataset for Nuclei Instance Segmentation of Cryosectioned H&E-Stained Histological Images](https://mlsanity.com/paper/2101.00442/) (2021)
- [A Generalized Deep Learning Framework for Whole-Slide Image Segmentation and Analysis](https://mlsanity.com/paper/2001.00258/) (2020)
- [Deep Semi-supervised Knowledge Distillation for Overlapping Cervical Cell Instance Segmentation](https://mlsanity.com/paper/2007.10787/) (2020)
- [Noisy Boundaries: Lemon or Lemonade for Semi-supervised Instance Segmentation?](https://mlsanity.com/paper/2203.13427/) (2022)
- [The Devil is in the Points: Weakly Semi-Supervised Instance Segmentation via Point-Guided Mask Representation](https://mlsanity.com/paper/2303.15062/) (2023)
- [Pseudo-label Alignment for Semi-supervised Instance Segmentation](https://mlsanity.com/paper/2308.05359/) (2023)

## Built on by (most cited first, 5 of 5)

- [Unified Language-driven Zero-shot Domain Adaptation](https://mlsanity.com/paper/2404.07155/) (2024)
- [DAWN: Domain-Adaptive Weakly Supervised Nuclei Segmentation via Cross-Task Interactions](https://mlsanity.com/paper/2404.14956/) (2024)
- [Dynamic Pseudo Label Optimization in Point-Supervised Nuclei Segmentation](https://mlsanity.com/paper/2406.16427/) (2024)
- [Spatio-Temporal Representation Decoupling and Enhancement for Federated Instrument Segmentation in Surgical Videos](https://mlsanity.com/paper/2506.23759/) (2025)
- [Intra-Class Subdivision for Pixel Contrastive Learning: Application to Semi-supervised Cardiac Image Segmentation](https://mlsanity.com/paper/2602.00174/) (2026)

## Abstract (arXiv)

Semi-supervised segmentation methods have demonstrated promising results in natural scenarios, providing a solution to reduce dependency on manual annotation. However, these methods face significant challenges when directly applied to pathological images due to the subtle color differences between nuclei and tissues, as well as the significant morphological variations among nuclei. Consequently, the generated pseudo-labels often contain much noise, especially at the nuclei boundaries. To address the above problem, this paper proposes a boundary-aware contrastive learning network to denoise the boundary noise in a semi-supervised nuclei segmentation task. The model has two key designs: a low-resolution denoising (LRD) module and a cross-RoI contrastive learning (CRC) module. The LRD improves the smoothness of the nuclei boundary by pseudo-labels denoising, and the CRC enhances the discrimination between foreground and background by boundary feature contrastive learning. We conduct extensive experiments to demonstrate the superiority of our proposed method over existing semi-supervised instance segmentation methods.