# DoseGNN: Improving the Performance of Deep Learning Models in Adaptive Dose-Volume Histogram Prediction through Graph Neural Networks

arXiv: https://arxiv.org/abs/2402.01076 · HTML: https://mlsanity.com/paper/2402.01076/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 30 references that are in the map.
- First posted on arXiv 2 Feb 2024.

## Builds on (most cited first, 12 of 12)

- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Inductive Representation Learning on Large Graphs](https://mlsanity.com/paper/1706.02216/) (2017)
- [How Powerful are Graph Neural Networks?](https://mlsanity.com/paper/1810.00826/) (2018)
- [Neural Message Passing for Quantum Chemistry](https://mlsanity.com/paper/1704.01212/) (2017)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Convolutional Networks on Graphs for Learning Molecular Fingerprints](https://mlsanity.com/paper/1509.09292/) (2015)
- [A Survey on Visual Transformer](https://mlsanity.com/paper/2012.12556/) (2020)
- [GraphRNN: Generating Realistic Graphs with Deep Auto-regressive Models](https://mlsanity.com/paper/1802.08773/) (2018)
- [CktGNN: Circuit Graph Neural Network for Electronic Design Automation](https://mlsanity.com/paper/2308.16406/) (2023)
- [PACE: A Parallelizable Computation Encoder for Directed Acyclic Graphs](https://mlsanity.com/paper/2203.10304/) (2022)
- [Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling](https://mlsanity.com/paper/2209.09245/) (2022)

## Built on by (most cited first, 2 of 2)

- [Highly Accurate Disease Diagnosis and Highly Reproducible Biomarker Identification with PathFormer](https://mlsanity.com/paper/2402.07268/) (2024)
- [Large-Language-Model Empowered Dose Volume Histogram Prediction for Intensity Modulated Radiotherapy](https://mlsanity.com/paper/2402.07167/) (2024)

## Abstract (arXiv)

Dose-Volume Histogram (DVH) prediction is fundamental in radiation therapy that facilitate treatment planning, dose evaluation, plan comparison and etc. It helps to increase the ability to deliver precise and effective radiation treatments while managing potential toxicities to healthy tissues as needed to reduce the risk of complications. This paper extends recently disclosed research findings presented on AAPM (AAPM 65th Annual Meeting & Exhibition) and includes necessary technique details. The objective is to design efficient deep learning models for DVH prediction on general radiotherapy platform equipped with high performance CBCT system, where input CT images and target dose images to predict may have different origins, spacing and sizes. Deep learning models widely-adopted in DVH prediction task are evaluated on the novel radiotherapy platform, and graph neural networks (GNNs) are shown to be the ideal architecture to construct a plug-and-play framework to improve predictive performance of base deep learning models in the adaptive setting.