# Predicting Hypoxia in Brain Tumors from Multiparametric MRI

arXiv: https://arxiv.org/abs/2401.14171 · HTML: https://mlsanity.com/paper/2401.14171/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 37 references that are in the map.
- First posted on arXiv 25 Jan 2024.

## Builds on (most cited first, 8 of 8)

- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Efficient Multi-Scale 3D CNN with Fully Connected CRF for Accurate Brain Lesion Segmentation](https://mlsanity.com/paper/1603.05959/) (2016)
- [ResViT: Residual vision transformers for multi-modal medical image synthesis](https://mlsanity.com/paper/2106.16031/) (2021)
- [Cross-Modality Synthesis from CT to PET using FCN and GAN Networks for Improved Automated Lesion Detection](https://mlsanity.com/paper/1802.07846/) (2018)
- [Synthesizing PET images from High-field and Ultra-high-field MR images Using Joint Diffusion Attention Model](https://mlsanity.com/paper/2305.03901/) (2023)
- [Generative Adversarial Networks for Brain Images Synthesis: A Review](https://mlsanity.com/paper/2305.15421/) (2023)
- [Synthetic PET via Domain Translation of 3D MRI](https://mlsanity.com/paper/2206.05618/) (2022)
- [U-PET: MRI-based Dementia Detection with Joint Generation of Synthetic FDG-PET Images](https://mlsanity.com/paper/2206.08078/) (2022)

## Abstract (arXiv)

This research paper presents a novel approach to the prediction of hypoxia in brain tumors, using multi-parametric Magnetic Resonance Imaging (MRI). Hypoxia, a condition characterized by low oxygen levels, is a common feature of malignant brain tumors associated with poor prognosis. Fluoromisonidazole Positron Emission Tomography (FMISO PET) is a well-established method for detecting hypoxia in vivo, but it is expensive and not widely available. Our study proposes the use of MRI, a more accessible and cost-effective imaging modality, to predict FMISO PET signals. We investigate deep learning models (DL) trained on the ACRIN 6684 dataset, a resource that contains paired MRI and FMISO PET images from patients with brain tumors. Our trained models effectively learn the complex relationships between the MRI features and the corresponding FMISO PET signals, thereby enabling the prediction of hypoxia from MRI scans alone. The results show a strong correlation between the predicted and actual FMISO PET signals, with an overall PSNR score above 29.6 and a SSIM score greater than 0.94, confirming MRI as a promising option for hypoxia prediction in brain tumors. This approach could significantly improve the accessibility of hypoxia detection in clinical settings, with the potential for more timely and targeted treatments.