# SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation

arXiv: https://arxiv.org/abs/2401.13560 · HTML: https://mlsanity.com/paper/2401.13560/

## Key facts

- Cited by 266 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 22 of its 33 references that are in the map.
- First posted on arXiv 24 Jan 2024.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 22 of 22)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Model](https://mlsanity.com/paper/2401.09417/) (2024)
- [VMamba: Visual State Space Model](https://mlsanity.com/paper/2401.10166/) (2024)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [Pay Attention to MLPs](https://mlsanity.com/paper/2105.08050/) (2021)
- [3D MRI brain tumor segmentation using autoencoder regularization](https://mlsanity.com/paper/1810.11654/) (2018)
- [TransBTS: Multimodal Brain Tumor Segmentation Using Transformer](https://mlsanity.com/paper/2103.04430/) (2021)
- [MedNeXt: Transformer-driven Scaling of ConvNets for Medical Image Segmentation](https://mlsanity.com/paper/2303.09975/) (2023)
- [Better Aggregation in Test-Time Augmentation](https://mlsanity.com/paper/2011.11156/) (2020)
- [3D UX-Net: A Large Kernel Volumetric ConvNet Modernizing Hierarchical Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2209.15076/) (2022)
- [The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs)](https://mlsanity.com/paper/2305.17033/) (2023)
- [Diff-UNet: A Diffusion Embedded Network for Volumetric Segmentation](https://mlsanity.com/paper/2303.10326/) (2023)
- [NestedFormer: Nested Modality-Aware Transformer for Brain Tumor Segmentation](https://mlsanity.com/paper/2208.14876/) (2022)
- [LKD-Net: Large Kernel Convolution Network for Single Image Dehazing](https://mlsanity.com/paper/2209.01788/) (2022)
- [HybridMIM: A Hybrid Masked Image Modeling Framework for 3D Medical Image Segmentation](https://mlsanity.com/paper/2303.10333/) (2023)
- [Hunting imaging biomarkers in pulmonary fibrosis: Benchmarks of the AIIB23 challenge](https://mlsanity.com/paper/2312.13752/) (2023)

## Built on by (most cited first, 30 of 266)

- [MambaIR: A Simple Baseline for Image Restoration with State-Space Model](https://mlsanity.com/paper/2402.15648/) (2024)
- [VM-UNet: Vision Mamba UNet for Medical Image Segmentation](https://mlsanity.com/paper/2402.02491/) (2024)
- [nnU-Net Revisited: A Call for Rigorous Validation in 3D Medical Image Segmentation](https://mlsanity.com/paper/2404.09556/) (2024)
- [LocalMamba: Visual State Space Model with Windowed Selective Scan](https://mlsanity.com/paper/2403.09338/) (2024)
- [Swin-UMamba: Mamba-based UNet with ImageNet-based pretraining](https://mlsanity.com/paper/2402.03302/) (2024)
- [U-KAN Makes Strong Backbone for Medical Image Segmentation and Generation](https://mlsanity.com/paper/2406.02918/) (2024)
- [PointMamba: A Simple State Space Model for Point Cloud Analysis](https://mlsanity.com/paper/2402.10739/) (2024)
- [EfficientVMamba: Atrous Selective Scan for Light Weight Visual Mamba](https://mlsanity.com/paper/2403.09977/) (2024)
- [Mamba-UNet: UNet-Like Pure Visual Mamba for Medical Image Segmentation](https://mlsanity.com/paper/2402.05079/) (2024)
- [VL-Mamba: Exploring State Space Models for Multimodal Learning](https://mlsanity.com/paper/2403.13600/) (2024)
- [The Hidden Attention of Mamba Models](https://mlsanity.com/paper/2403.01590/) (2024)
- [Graph Mamba: Towards Learning on Graphs with State Space Models](https://mlsanity.com/paper/2402.08678/) (2024)
- [ZigMa: A DiT-style Zigzag Mamba Diffusion Model](https://mlsanity.com/paper/2403.13802/) (2024)
- [Pan-Mamba: Effective pan-sharpening with State Space Model](https://mlsanity.com/paper/2402.12192/) (2024)
- [Sigma: Siamese Mamba Network for Multi-Modal Semantic Segmentation](https://mlsanity.com/paper/2404.04256/) (2024)
- [Point Cloud Mamba: Point Cloud Learning via State Space Model](https://mlsanity.com/paper/2403.00762/) (2024)
- [Mamba-360: Survey of State Space Models as Transformer Alternative for Long Sequence Modelling: Methods, Applications, and Challenges](https://mlsanity.com/paper/2404.16112/) (2024)
- [MiM-ISTD: Mamba-in-Mamba for Efficient Infrared Small Target Detection](https://mlsanity.com/paper/2403.02148/) (2024)
- [State Space Model for New-Generation Network Alternative to Transformers: A Survey](https://mlsanity.com/paper/2404.09516/) (2024)
- [LightM-UNet: Mamba Assists in Lightweight UNet for Medical Image Segmentation](https://mlsanity.com/paper/2403.05246/) (2024)
- [Vision Mamba: A Comprehensive Survey and Taxonomy](https://mlsanity.com/paper/2405.04404/) (2024)
- [A Survey on Visual Mamba](https://mlsanity.com/paper/2404.15956/) (2024)
- [CDMamba: Incorporating Local Clues into Mamba for Remote Sensing Image Binary Change Detection](https://mlsanity.com/paper/2406.04207/) (2024)
- [nnMamba: 3D Biomedical Image Segmentation, Classification and Landmark Detection with State Space Model](https://mlsanity.com/paper/2402.03526/) (2024)
- [ReMamber: Referring Image Segmentation with Mamba Twister](https://mlsanity.com/paper/2403.17839/) (2024)
- [SSAMBA: Self-Supervised Audio Representation Learning with Mamba State Space Model](https://mlsanity.com/paper/2405.11831/) (2024)
- [Audio Mamba: Bidirectional State Space Model for Audio Representation Learning](https://mlsanity.com/paper/2406.03344/) (2024)
- [VMRNN: Integrating Vision Mamba and LSTM for Efficient and Accurate Spatiotemporal Forecasting](https://mlsanity.com/paper/2403.16536/) (2024)
- [LKM-UNet: Large Kernel Vision Mamba UNet for Medical Image Segmentation](https://mlsanity.com/paper/2403.07332/) (2024)
- [MambaLRP: Explaining Selective State Space Sequence Models](https://mlsanity.com/paper/2406.07592/) (2024)

## Abstract (arXiv)

The Transformer architecture has shown a remarkable ability in modeling global relationships. However, it poses a significant computational challenge when processing high-dimensional medical images. This hinders its development and widespread adoption in this task. Mamba, as a State Space Model (SSM), recently emerged as a notable manner for long-range dependencies in sequential modeling, excelling in natural language processing filed with its remarkable memory efficiency and computational speed. Inspired by its success, we introduce SegMamba, a novel 3D medical image Segmentation Mamba model, designed to effectively capture long-range dependencies within whole volume features at every scale. Our SegMamba, in contrast to Transformer-based methods, excels in whole volume feature modeling from a state space model standpoint, maintaining superior processing speed, even with volume features at a resolution of 64× 64× 64. Comprehensive experiments on the BraTS2023 dataset demonstrate the effectiveness and efficiency of our SegMamba. The code for SegMamba is available at: https://github.com/ge-xing/SegMamba