# MITS-GAN: Safeguarding Medical Imaging from Tampering with Generative Adversarial Networks

arXiv: https://arxiv.org/abs/2401.09624 · HTML: https://mlsanity.com/paper/2401.09624/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 46 of its 68 references that are in the map.
- First posted on arXiv 17 Jan 2024.

## Builds on (most cited first, 30 of 46)

- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Explaining and Harnessing Adversarial Examples](https://mlsanity.com/paper/1412.6572/) (2014)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Progressive Growing of GANs for Improved Quality, Stability, and Variation](https://mlsanity.com/paper/1710.10196/) (2017)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [DeepFool: a simple and accurate method to fool deep neural networks](https://mlsanity.com/paper/1511.04599/) (2015)
- [StarGAN v2: Diverse Image Synthesis for Multiple Domains](https://mlsanity.com/paper/1912.01865/) (2019)
- [SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <0.5MB model size](https://mlsanity.com/paper/1602.07360/) (2016)
- [CNN-generated images are surprisingly easy to spot... for now](https://mlsanity.com/paper/1912.11035/) (2019)
- [Universal adversarial perturbations](https://mlsanity.com/paper/1610.08401/) (2016)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [Face X-ray for More General Face Forgery Detection](https://mlsanity.com/paper/1912.13458/) (2019)
- [Detecting and Simulating Artifacts in GAN Fake Images](https://mlsanity.com/paper/1907.06515/) (2019)
- [On the detection of synthetic images generated by diffusion models](https://mlsanity.com/paper/2211.00680/) (2022)
- [Watch your Up-Convolution: CNN Based Generative Deep Neural Networks are Failing to Reproduce Spectral Distributions](https://mlsanity.com/paper/2003.01826/) (2020)
- [Adversarial Examples for Semantic Segmentation and Object Detection](https://mlsanity.com/paper/1703.08603/) (2017)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Do GANs leave artificial fingerprints?](https://mlsanity.com/paper/1812.11842/) (2018)
- [Capsule-Forensics: Using Capsule Networks to Detect Forged Images and Videos](https://mlsanity.com/paper/1810.11215/) (2018)
- [Fourier Spectrum Discrepancies in Deep Network Generated Images](https://mlsanity.com/paper/1911.06465/) (2019)
- [M2TR: Multi-modal Multi-scale Transformers for Deepfake Detection](https://mlsanity.com/paper/2104.09770/) (2021)
- [ID-Reveal: Identity-aware DeepFake Video Detection](https://mlsanity.com/paper/2012.02512/) (2020)
- [Universal Adversarial Perturbations Against Semantic Image Segmentation](https://mlsanity.com/paper/1704.05712/) (2017)
- [Deepfakes Generation and Detection: State-of-the-art, open challenges, countermeasures, and way forward](https://mlsanity.com/paper/2103.00484/) (2021)
- [Combining EfficientNet and Vision Transformers for Video Deepfake Detection](https://mlsanity.com/paper/2107.02612/) (2021)
- [DeepFake Detection by Analyzing Convolutional Traces](https://mlsanity.com/paper/2004.10448/) (2020)
- [Deepfake Video Detection Using Convolutional Vision Transformer](https://mlsanity.com/paper/2102.11126/) (2021)
- [Generating Adversarial Malware Examples for Black-Box Attacks Based on GAN](https://mlsanity.com/paper/1702.05983/) (2017)
- [Disrupting Deepfakes: Adversarial Attacks Against Conditional Image Translation Networks and Facial Manipulation Systems](https://mlsanity.com/paper/2003.01279/) (2020)
- [Unsupervised Cross-Modality Domain Adaptation of ConvNets for Biomedical Image Segmentations with Adversarial Loss](https://mlsanity.com/paper/1804.10916/) (2018)

## Built on by (most cited first, 1 of 1)

- [Provenance-Driven Reliable Semantic Medical Image Vector Reconstruction via Lightweight Blockchain-Verified Latent Fingerprints](https://mlsanity.com/paper/2512.00999/) (2025)

## Abstract (arXiv)

The progress in generative models, particularly Generative Adversarial Networks (GANs), opened new possibilities for image generation but raised concerns about potential malicious uses, especially in sensitive areas like medical imaging. This study introduces MITS-GAN, a novel approach to prevent tampering in medical images, with a specific focus on CT scans. The approach disrupts the output of the attacker's CT-GAN architecture by introducing finely tuned perturbations that are imperceptible to the human eye. Specifically, the proposed approach involves the introduction of appropriate Gaussian noise to the input as a protective measure against various attacks. Our method aims to enhance tamper resistance, comparing favorably to existing techniques. Experimental results on a CT scan demonstrate MITS-GAN's superior performance, emphasizing its ability to generate tamper-resistant images with negligible artifacts. As image tampering in medical domains poses life-threatening risks, our proactive approach contributes to the responsible and ethical use of generative models. This work provides a foundation for future research in countering cyber threats in medical imaging. Models and codes are publicly available on https://iplab.dmi.unict.it/MITS-GAN-2024/.