# Large language models in healthcare and medical domain: A review

arXiv: https://arxiv.org/abs/2401.06775 · HTML: https://mlsanity.com/paper/2401.06775/

## Key facts

- Cited by 127 papers in the map (data through 14 Oct 2026).
- Builds on 70 of its 135 references that are in the map.
- First posted on arXiv 12 Dec 2023.

## Builds on (most cited first, 30 of 70)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Finetuned Language Models Are Zero-Shot Learners](https://mlsanity.com/paper/2109.01652/) (2021)
- [Switch Transformers: Scaling to Trillion Parameter Models with Simple and Efficient Sparsity](https://mlsanity.com/paper/2101.03961/) (2021)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Language Models as Knowledge Bases?](https://mlsanity.com/paper/1909.01066/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [PaLM 2 Technical Report](https://mlsanity.com/paper/2305.10403/) (2023)
- [A Survey on Multimodal Large Language Models](https://mlsanity.com/paper/2306.13549/) (2023)
- [GLaM: Efficient Scaling of Language Models with Mixture-of-Experts](https://mlsanity.com/paper/2112.06905/) (2021)
- [Visual ChatGPT: Talking, Drawing and Editing with Visual Foundation Models](https://mlsanity.com/paper/2303.04671/) (2023)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [A Survey of Hallucination in Large Foundation Models](https://mlsanity.com/paper/2309.05922/) (2023)
- [Explainability for Large Language Models: A Survey](https://mlsanity.com/paper/2309.01029/) (2023)
- [GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Records](https://mlsanity.com/paper/2203.03540/) (2022)
- [Language models show human-like content effects on reasoning tasks](https://mlsanity.com/paper/2207.07051/) (2022)
- [A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics](https://mlsanity.com/paper/2310.05694/) (2023)

## Built on by (most cited first, 30 of 127)

- [A Survey of Mathematical Reasoning in the Era of Multimodal Large Language Model: Benchmark, Method & Challenges](https://mlsanity.com/paper/2412.11936/) (2024)
- [The State of Multilingual LLM Safety Research: From Measuring the Language Gap to Mitigating It](https://mlsanity.com/paper/2505.24119/) (2025)
- [LLM-MedQA: Enhancing Medical Question Answering through Case Studies in Large Language Models](https://mlsanity.com/paper/2501.05464/) (2024)
- [FHIR-AgentBench: Benchmarking LLM Agents for Realistic Interoperable EHR Question Answering](https://mlsanity.com/paper/2509.19319/) (2025)
- [Mitigating the Risk of Health Inequity Exacerbated by Large Language Models](https://mlsanity.com/paper/2410.05180/) (2024)
- [Fairness and Bias in Multimodal AI: A Survey](https://mlsanity.com/paper/2406.19097/) (2024)
- [Efficient Fine-Tuning of Large Language Models for Automated Medical Documentation](https://mlsanity.com/paper/2409.09324/) (2024)
- [CacheClip: Accelerating RAG with Effective KV Cache Reuse](https://mlsanity.com/paper/2510.10129/) (2025)
- [MedArabiQ: Benchmarking Large Language Models on Arabic Medical Tasks](https://mlsanity.com/paper/2505.03427/) (2025)
- [The Sociolinguistic Foundations of Language Modeling](https://mlsanity.com/paper/2407.09241/) (2024)
- [Agentic Medical Knowledge Graphs Enhance Medical Question Answering: Bridging the Gap Between LLMs and Evolving Medical Knowledge](https://mlsanity.com/paper/2502.13010/) (2025)
- [Large Means Left: Political Bias in Large Language Models Increases with Their Number of Parameters](https://mlsanity.com/paper/2505.04393/) (2025)
- [Look Within, Why LLMs Hallucinate: A Causal Perspective](https://mlsanity.com/paper/2407.10153/) (2024)
- [Gatekeeper: Improving Model Cascades Through Confidence Tuning](https://mlsanity.com/paper/2502.19335/) (2025)
- [LExT: Towards Evaluating Trustworthiness of Natural Language Explanations](https://mlsanity.com/paper/2504.06227/) (2025)
- [MedSentry: Understanding and Mitigating Safety Risks in Medical LLM Multi-Agent Systems](https://mlsanity.com/paper/2505.20824/) (2025)
- [Polish-English medical knowledge transfer: A new benchmark and results](https://mlsanity.com/paper/2412.00559/) (2024)
- [Surgical Scene Understanding in the Era of Foundation AI Models: A Comprehensive Review](https://mlsanity.com/paper/2502.14886/) (2025)
- [Shallow Robustness, Deep Vulnerabilities: Multi-Turn Evaluation of Medical LLMs](https://mlsanity.com/paper/2510.12255/) (2025)
- [CLIMB: A Benchmark of Clinical Bias in Large Language Models](https://mlsanity.com/paper/2407.05250/) (2024)
- [Abstraction Alignment: Comparing Model-Learned and Human-Encoded Conceptual Relationships](https://mlsanity.com/paper/2407.12543/) (2024)
- [Trustworthy Medical Question Answering: An Evaluation-Centric Survey](https://mlsanity.com/paper/2506.03659/) (2025)
- [The Foundational Capabilities of Large Language Models in Predicting Postoperative Risks Using Clinical Notes](https://mlsanity.com/paper/2402.17493/) (2024)
- [PromptMind Team at MEDIQA-CORR 2024: Improving Clinical Text Correction with Error Categorization and LLM Ensembles](https://mlsanity.com/paper/2405.08373/) (2024)
- [Fine Tuning Large Language Models for Medicine: The Role and Importance of Direct Preference Optimization](https://mlsanity.com/paper/2409.12741/) (2024)
- [Susceptibility of Large Language Models to User-Driven Factors in Medical Queries](https://mlsanity.com/paper/2503.22746/) (2025)
- [FairMedQA: Benchmarking Bias in Large Language Models for Medical Question Answering](https://mlsanity.com/paper/2505.19562/) (2025)
- [Beyond Multiple-Choice Accuracy: Real-World Challenges of Implementing Large Language Models in Healthcare](https://mlsanity.com/paper/2410.18460/) (2024)
- [Electronic Circuit Principles of Large Language Models](https://mlsanity.com/paper/2502.03325/) (2025)
- [An LLM-Powered Agent for Physiological Data Analysis: A Case Study on PPG-based Heart Rate Estimation](https://mlsanity.com/paper/2502.12836/) (2025)

## Abstract (arXiv)

The deployment of large language models (LLMs) within the healthcare sector has sparked both enthusiasm and apprehension. These models exhibit the remarkable capability to provide proficient responses to free-text queries, demonstrating a nuanced understanding of professional medical knowledge. This comprehensive survey delves into the functionalities of existing LLMs designed for healthcare applications, elucidating the trajectory of their development, starting from traditional Pretrained Language Models (PLMs) to the present state of LLMs in healthcare sector. First, we explore the potential of LLMs to amplify the efficiency and effectiveness of diverse healthcare applications, particularly focusing on clinical language understanding tasks. These tasks encompass a wide spectrum, ranging from named entity recognition and relation extraction to natural language inference, multi-modal medical applications, document classification, and question-answering. Additionally, we conduct an extensive comparison of the most recent state-of-the-art LLMs in the healthcare domain, while also assessing the utilization of various open-source LLMs and highlighting their significance in healthcare applications. Furthermore, we present the essential performance metrics employed to evaluate LLMs in the biomedical domain, shedding light on their effectiveness and limitations. Finally, we summarize the prominent challenges and constraints faced by large language models in the healthcare sector, offering a holistic perspective on their potential benefits and shortcomings. This review provides a comprehensive exploration of the current landscape of LLMs in healthcare, addressing their role in transforming medical applications and the areas that warrant further research and development.