# MPRE: Multi-perspective Patient Representation Extractor for Disease Prediction

arXiv: https://arxiv.org/abs/2401.00756 · HTML: https://mlsanity.com/paper/2401.00756/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 50 references that are in the map.
- First posted on arXiv 1 Jan 2024.

## Builds on (most cited first, 14 of 14)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Empirical Evaluation of Gated Recurrent Neural Networks on Sequence Modeling](https://mlsanity.com/paper/1412.3555/) (2014)
- [Multi-Scale Context Aggregation by Dilated Convolutions](https://mlsanity.com/paper/1511.07122/) (2015)
- [On the Convergence of Adam and Beyond](https://mlsanity.com/paper/1904.09237/) (2019)
- [Temporal Convolutional Networks for Action Segmentation and Detection](https://mlsanity.com/paper/1611.05267/) (2016)
- [RETAIN: An Interpretable Predictive Model for Healthcare using Reverse Time Attention Mechanism](https://mlsanity.com/paper/1608.05745/) (2016)
- [Dipole: Diagnosis Prediction in Healthcare via Attention-based Bidirectional Recurrent Neural Networks](https://mlsanity.com/paper/1706.05764/) (2017)
- [Attend and Diagnose: Clinical Time Series Analysis using Attention Models](https://mlsanity.com/paper/1711.03905/) (2017)
- [M3Care: Learning with Missing Modalities in Multimodal Healthcare Data](https://mlsanity.com/paper/2210.17292/) (2022)
- [Multilevel Wavelet Decomposition Network for Interpretable Time Series Analysis](https://mlsanity.com/paper/1806.08946/) (2018)
- [ConCare: Personalized Clinical Feature Embedding via Capturing the Healthcare Context](https://mlsanity.com/paper/1911.12216/) (2019)
- [AdaCare: Explainable Clinical Health Status Representation Learning via Scale-Adaptive Feature Extraction and Recalibration](https://mlsanity.com/paper/1911.12205/) (2019)
- [StageNet: Stage-Aware Neural Networks for Health Risk Prediction](https://mlsanity.com/paper/2001.10054/) (2020)
- [Dynamic Prediction of ICU Mortality Risk Using Domain Adaptation](https://mlsanity.com/paper/1912.10080/) (2019)

## Abstract (arXiv)

Patient representation learning based on electronic health records (EHR) is a critical task for disease prediction. This task aims to effectively extract useful information on dynamic features. Although various existing works have achieved remarkable progress, the model performance can be further improved by fully extracting the trends, variations, and the correlation between the trends and variations in dynamic features. In addition, sparse visit records limit the performance of deep learning models. To address these issues, we propose the Multi-perspective Patient Representation Extractor (MPRE) for disease prediction. Specifically, we propose Frequency Transformation Module (FTM) to extract the trend and variation information of dynamic features in the time-frequency domain, which can enhance the feature representation. In the 2D Multi-Extraction Network (2D MEN), we form the 2D temporal tensor based on trend and variation. Then, the correlations between trend and variation are captured by the proposed dilated operation. Moreover, we propose the First-Order Difference Attention Mechanism (FODAM) to calculate the contributions of differences in adjacent variations to the disease diagnosis adaptively. To evaluate the performance of MPRE and baseline methods, we conduct extensive experiments on two real-world public datasets. The experiment results show that MPRE outperforms state-of-the-art baseline methods in terms of AUROC and AUPRC.