# Resource-Limited Automated Ki67 Index Estimation in Breast Cancer

arXiv: https://arxiv.org/abs/2401.00014 · HTML: https://mlsanity.com/paper/2401.00014/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 56 references that are in the map.
- First posted on arXiv 22 Dec 2023.

## Builds on (most cited first, 11 of 11)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Deep Compression: Compressing Deep Neural Networks with Pruning, Trained Quantization and Huffman Coding](https://mlsanity.com/paper/1510.00149/) (2015)
- [Federated Learning: Challenges, Methods, and Future Directions](https://mlsanity.com/paper/1908.07873/) (2019)
- [ShuffleNet: An Extremely Efficient Convolutional Neural Network for Mobile Devices](https://mlsanity.com/paper/1707.01083/) (2017)
- [Learning and Generalization in Overparameterized Neural Networks, Going Beyond Two Layers](https://mlsanity.com/paper/1811.04918/) (2018)
- [A Systematic Collection of Medical Image Datasets for Deep Learning](https://mlsanity.com/paper/2106.12864/) (2021)
- [Universal Deep Neural Network Compression](https://mlsanity.com/paper/1802.02271/) (2018)
- [Action2Activity: Recognizing Complex Activities from Sensor Data](https://mlsanity.com/paper/1611.01872/) (2016)
- [Compression strategies and space-conscious representations for deep neural networks](https://mlsanity.com/paper/2007.07967/) (2020)
- [I-Health: Leveraging Edge Computing and Blockchain for Epidemic Management](https://mlsanity.com/paper/2012.14294/) (2020)

## Abstract (arXiv)

The prediction of tumor progression and chemotherapy response has been recently tackled exploiting Tumor Infiltrating Lymphocytes (TILs) and the nuclear protein Ki67 as prognostic factors. Recently, deep neural networks (DNNs) have been shown to achieve top results in estimating Ki67 expression and simultaneous determination of intratumoral TILs score in breast cancer cells. However, in the last ten years the extraordinary progress induced by deep models proliferated at least as much as their resource demand. The exorbitant computational costs required to query (and in some cases also to store) a deep model represent a strong limitation in resource-limited contexts, like that of IoT-based applications to support healthcare personnel. To this end, we propose a resource consumption-aware DNN for the effective estimate of the percentage of Ki67-positive cells in breast cancer screenings. Our approach reduced up to 75% and 89% the usage of memory and disk space respectively, up to 1.5x the energy consumption, and preserved or improved the overall accuracy of a benchmark state-of-the-art solution. Encouraged by such positive results, we developed and structured the adopted framework so as to allow its general purpose usage, along with a public software repository to support its usage.