# Ultrasound Image Enhancement using CycleGAN and Perceptual Loss

arXiv: https://arxiv.org/abs/2312.11748 · HTML: https://mlsanity.com/paper/2312.11748/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 8 of its 20 references that are in the map.
- First posted on arXiv 18 Dec 2023.

## Builds on (most cited first, 8 of 8)

- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [MedGAN: Medical Image Translation using GANs](https://mlsanity.com/paper/1806.06397/) (2018)
- [Distribution Matching Losses Can Hallucinate Features in Medical Image Translation](https://mlsanity.com/paper/1805.08841/) (2018)
- [Translating and Segmenting Multimodal Medical Volumes with Cycle- and Shape-Consistency Generative Adversarial Network](https://mlsanity.com/paper/1802.09655/) (2018)
- [Attention-GAN for Object Transfiguration in Wild Images](https://mlsanity.com/paper/1803.06798/) (2018)
- [Unsupervised/Semi-supervised Deep Learning for Low-dose CT Enhancement](https://mlsanity.com/paper/1808.02603/) (2018)

## Built on by (most cited first, 2 of 2)

- [Emulating Clinical Quality Muscle B-mode Ultrasound Images from Plane Wave Images Using a Two-Stage Machine Learning Model](https://mlsanity.com/paper/2412.05758/) (2024)
- [Focus on What Matters: Two-Stage ROI-Aware Refinement for Anatomy-Preserving Fetal Ultrasound Reconstruction](https://mlsanity.com/paper/2604.23839/) (2026)

## Abstract (arXiv)

Purpose: The objective of this work is to introduce an advanced framework designed to enhance ultrasound images, especially those captured by portable hand-held devices, which often produce lower quality images due to hardware constraints. Additionally, this framework is uniquely capable of effectively handling non-registered input ultrasound image pairs, addressing a common challenge in medical imaging. Materials and Methods: In this retrospective study, we utilized an enhanced generative adversarial network (CycleGAN) model for ultrasound image enhancement across five organ systems. Perceptual loss, derived from deep features of pretrained neural networks, is applied to ensure the human-perceptual quality of the enhanced images. These images are compared with paired images acquired from high resolution devices to demonstrate the model's ability to generate realistic high-quality images across organ systems. Results: Preliminary validation of the framework reveals promising performance metrics. The model generates images that result in a Structural Similarity Index (SSI) score of 0.722, Locally Normalized Cross-Correlation (LNCC) score of 0.902 and 28.802 for the Peak Signal-to-Noise Ratio (PSNR) metric. Conclusion: This work presents a significant advancement in medical imaging through the development of a CycleGAN model enhanced with Perceptual Loss (PL), effectively bridging the quality gap between ultrasound images from varied devices. By training on paired images, the model not only improves image quality but also ensures the preservation of vital anatomic structural content. This approach may improve equity in access to healthcare by enhancing portable device capabilities, although further validation and optimizations are necessary for broader clinical application.