# Image is All You Need to Empower Large-scale Diffusion Models for In-Domain Generation

arXiv: https://arxiv.org/abs/2312.08195 · HTML: https://mlsanity.com/paper/2312.08195/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Placed in Diffusion foundations and sampling, one of 14 directions in Diffusion models.
- Builds on 55 of its 61 references that are in the map.
- First posted on arXiv 13 Dec 2023.

## Placed in

- Diffusion models / [Diffusion foundations and sampling](https://mlsanity.com/diffusion/diffusion-foundations-and-sampling/)

## Builds on (most cited first, 30 of 55)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [DreamFusion: Text-to-3D using 2D Diffusion](https://mlsanity.com/paper/2209.14988/) (2022)
- [Prompt-to-Prompt Image Editing with Cross Attention Control](https://mlsanity.com/paper/2208.01626/) (2022)
- [An Image is Worth One Word: Personalizing Text-to-Image Generation using Textual Inversion](https://mlsanity.com/paper/2208.01618/) (2022)
- [SDEdit: Guided Image Synthesis and Editing with Stochastic Differential Equations](https://mlsanity.com/paper/2108.01073/) (2021)
- [LAION-400M: Open Dataset of CLIP-Filtered 400 Million Image-Text Pairs](https://mlsanity.com/paper/2111.02114/) (2021)
- [Zero-1-to-3: Zero-shot One Image to 3D Object](https://mlsanity.com/paper/2303.11328/) (2023)
- [T2I-Adapter: Learning Adapters to Dig out More Controllable Ability for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.08453/) (2023)
- [Imagic: Text-Based Real Image Editing with Diffusion Models](https://mlsanity.com/paper/2210.09276/) (2022)
- [Multi-Concept Customization of Text-to-Image Diffusion](https://mlsanity.com/paper/2212.04488/) (2022)
- [StarGAN v2: Diverse Image Synthesis for Multiple Domains](https://mlsanity.com/paper/1912.01865/) (2019)
- [DPM-Solver++: Fast Solver for Guided Sampling of Diffusion Probabilistic Models](https://mlsanity.com/paper/2211.01095/) (2022)
- [COCO-Stuff: Thing and Stuff Classes in Context](https://mlsanity.com/paper/1612.03716/) (2016)
- [GLIGEN: Open-Set Grounded Text-to-Image Generation](https://mlsanity.com/paper/2301.07093/) (2023)
- [DiffEdit: Diffusion-based semantic image editing with mask guidance](https://mlsanity.com/paper/2210.11427/) (2022)
- [Designing an Encoder for StyleGAN Image Manipulation](https://mlsanity.com/paper/2102.02766/) (2021)

## Built on by (most cited first, 7 of 7)

- [Controllable Generation with Text-to-Image Diffusion Models: A Survey](https://mlsanity.com/paper/2403.04279/) (2024)
- [Lifting by Image -- Leveraging Image Cues for Accurate 3D Human Pose Estimation](https://mlsanity.com/paper/2312.15636/) (2023)
- [OMEGAS: Object Mesh Extraction from Large Scenes Guided by Gaussian Segmentation](https://mlsanity.com/paper/2404.15891/) (2024)
- [Initialize to Generalize: A Stronger Initialization Pipeline for Sparse-View 3DGS](https://mlsanity.com/paper/2510.17479/) (2025)
- [DrawAI: Agentic Benchmark and Workflow for Making Raster Images Editable](https://mlsanity.com/paper/2608.00548/) (2026)
- [A Tilted Seesaw: Revisiting Autoencoder Trade-off for Controllable Diffusion](https://mlsanity.com/paper/2601.21633/) (2026)
- [KAN We Flow? Advancing Robotic Manipulation with 3D Flow Matching via KAN & RWKV](https://mlsanity.com/paper/2602.01115/) (2026)

## Abstract (arXiv)

In-domain generation aims to perform a variety of tasks within a specific domain, such as unconditional generation, text-to-image, image editing, 3D generation, and more. Early research typically required training specialized generators for each unique task and domain, often relying on fully-labeled data. Motivated by the powerful generative capabilities and broad applications of diffusion models, we are driven to explore leveraging label-free data to empower these models for in-domain generation. Fine-tuning a pre-trained generative model on domain data is an intuitive but challenging way and often requires complex manual hyper-parameter adjustments since the limited diversity of the training data can easily disrupt the model's original generative capabilities. To address this challenge, we propose a guidance-decoupled prior preservation mechanism to achieve high generative quality and controllability by image-only data, inspired by preserving the pre-trained model from a denoising guidance perspective. We decouple domain-related guidance from the conditional guidance used in classifier-free guidance mechanisms to preserve open-world control guidance and unconditional guidance from the pre-trained model. We further propose an efficient domain knowledge learning technique to train an additional text-free UNet copy to predict domain guidance. Besides, we theoretically illustrate a multi-guidance in-domain generation pipeline for a variety of generative tasks, leveraging multiple guidances from distinct diffusion models and conditions. Extensive experiments demonstrate the superiority of our method in domain-specific synthesis and its compatibility with various diffusion-based control methods and applications.