# CLIP in Medical Imaging: A Survey

arXiv: https://arxiv.org/abs/2312.07353 · HTML: https://mlsanity.com/paper/2312.07353/

## Key facts

- Cited by 40 papers in the map (data through 14 Oct 2026).
- Builds on 194 of its 319 references that are in the map.
- First posted on arXiv 12 Dec 2023.

## Builds on (most cited first, 30 of 194)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Shortcut Learning in Deep Neural Networks](https://mlsanity.com/paper/2004.07780/) (2020)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Barlow Twins: Self-Supervised Learning via Redundancy Reduction](https://mlsanity.com/paper/2103.03230/) (2021)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Reproducible scaling laws for contrastive language-image learning](https://mlsanity.com/paper/2212.07143/) (2022)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)

## Built on by (most cited first, 30 of 40)

- [Better Tokens for Better 3D: Advancing Vision-Language Modeling in 3D Medical Imaging](https://mlsanity.com/paper/2510.20639/) (2025)
- [Mind the Modality Gap: Towards a Remote Sensing Vision-Language Model via Cross-modal Alignment](https://mlsanity.com/paper/2402.09816/) (2024)
- [μ-Bench: A Vision-Language Benchmark for Microscopy Understanding](https://mlsanity.com/paper/2407.01791/) (2024)
- [On the Robustness of Medical Vision-Language Models: Are they Truly Generalizable?](https://mlsanity.com/paper/2505.15425/) (2025)
- [MedMoE: Modality-Specialized Mixture of Experts for Medical Vision-Language Understanding](https://mlsanity.com/paper/2506.08356/) (2025)
- [B-VLLM: A Vision Large Language Model with Balanced Spatio-Temporal Tokens](https://mlsanity.com/paper/2412.09919/) (2024)
- [Brain-Adapter: Enhancing Neurological Disorder Analysis with Adapter-Tuning Multimodal Large Language Models](https://mlsanity.com/paper/2501.16282/) (2025)
- [Explaining Similarity in Vision-Language Encoders with Weighted Banzhaf Interactions](https://mlsanity.com/paper/2508.05430/) (2025)
- [TextSAM-EUS: Text Prompt Learning for SAM to Accurately Segment Pancreatic Tumor in Endoscopic Ultrasound](https://mlsanity.com/paper/2507.18082/) (2025)
- [Dual Cross-image Semantic Consistency with Self-aware Pseudo Labeling for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2507.21440/) (2025)
- [MedCLIPSeg: Probabilistic Vision-Language Adaptation for Data-Efficient and Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2602.20423/) (2026)
- [Multimodal Medical Image Binding via Shared Text Embeddings](https://mlsanity.com/paper/2506.18072/) (2025)
- [Anatomy-VLM: A Fine-grained Vision-Language Model for Medical Interpretation](https://mlsanity.com/paper/2511.08402/) (2025)
- [Point, Detect, Count: Multi-Task Medical Image Understanding with Instruction-Tuned Vision-Language Models](https://mlsanity.com/paper/2505.16647/) (2025)
- [Generalist Models in Medical Image Segmentation: A Survey and Performance Comparison with Task-Specific Approaches](https://mlsanity.com/paper/2506.10825/) (2025)
- [Improvise, Adapt, Overcome -- Telescopic Adapters for Efficient Fine-tuning of Vision Language Models in Medical Imaging](https://mlsanity.com/paper/2512.13855/) (2025)
- [Enabling Ultra-Fast Cardiovascular Imaging Across Heterogeneous Clinical Environments with A Generalist Foundation Model and Multimodal Database](https://mlsanity.com/paper/2512.21652/) (2025)
- [Adapting Foundation Model for Dental Caries Detection with Dual-View Co-Training](https://mlsanity.com/paper/2508.20813/) (2025)
- [Exploring the Capabilities of Large Language Model Encoders for Image-Text Retrieval in Chest X-rays](https://mlsanity.com/paper/2509.15234/) (2025)
- [Revolutionizing Precise Low Back Pain Diagnosis via Contrastive Learning](https://mlsanity.com/paper/2509.20813/) (2025)
- [Surgeons Are Indian Males and Speech Therapists Are White Females: Auditing Biases in Vision-Language Models for Healthcare Professionals](https://mlsanity.com/paper/2510.06280/) (2025)
- [CHIPS: Efficient CLIP Adaptation via Curvature-aware Hybrid Influence-based Data Selection](https://mlsanity.com/paper/2511.18519/) (2025)
- [VL-OrdinalFormer: Vision Language Guided Ordinal Transformers for Interpretable Knee Osteoarthritis Grading](https://mlsanity.com/paper/2601.00879/) (2025)
- [Adapting Foundation Vision-Language Models to Medical Diagnosis via Query-Driven Expert Bridging](https://mlsanity.com/paper/2505.21698/) (2025)
- [Role-SynthCLIP: A Role Play Driven Diverse Synthetic Data Approach](https://mlsanity.com/paper/2511.05057/) (2025)
- [Beyond CLIP: Knowledge-Enhanced Multimodal Transformers for Cross-Modal Alignment in Diabetic Retinopathy Diagnosis](https://mlsanity.com/paper/2512.19663/) (2025)
- [CytoCLIP: Learning Cytoarchitectural Characteristics in Developing Human Brain Using Contrastive Language Image Pre-Training](https://mlsanity.com/paper/2601.12282/) (2026)
- [CauCLIP: Bridging the Sim-to-Real Gap in Surgical Video Understanding via Causality-Inspired Vision-Language Modeling](https://mlsanity.com/paper/2602.06619/) (2026)
- [XAI-CLIP: ROI-Guided Perturbation Framework for Explainable Medical Image Segmentation in Multimodal Vision-Language Models](https://mlsanity.com/paper/2602.07017/) (2026)
- [Foundation Models for Medical Imaging: Status, Challenges, and Directions](https://mlsanity.com/paper/2602.15913/) (2026)

## Abstract (arXiv)

Contrastive Language-Image Pre-training (CLIP), a simple yet effective pre-training paradigm, successfully introduces text supervision to vision models. It has shown promising results across various tasks due to its generalizability and interpretability. The use of CLIP has recently gained increasing interest in the medical imaging domain, serving as a pre-training paradigm for image-text alignment, or a critical component in diverse clinical tasks. With the aim of facilitating a deeper understanding of this promising direction, this survey offers an in-depth exploration of the CLIP within the domain of medical imaging, regarding both refined CLIP pre-training and CLIP-driven applications. In this paper, we (1) first start with a brief introduction to the fundamentals of CLIP methodology; (2) then investigate the adaptation of CLIP pre-training in the medical imaging domain, focusing on how to optimize CLIP given characteristics of medical images and reports; (3) further explore practical utilization of CLIP pre-trained models in various tasks, including classification, dense prediction, and cross-modal tasks; and (4) finally discuss existing limitations of CLIP in the context of medical imaging, and propose forward-looking directions to address the demands of medical imaging domain. Studies featuring technical and practical value are both investigated. We expect this survey will provide researchers with a holistic understanding of the CLIP paradigm and its potential implications. The project page of this survey can also be found on https://github.com/zhaozh10/Awesome-CLIP-in-Medical-Imaging.