# Predicting Bone Degradation Using Vision Transformer and Synthetic Cellular Microstructures Dataset

arXiv: https://arxiv.org/abs/2312.03133 · HTML: https://mlsanity.com/paper/2312.03133/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 14 references that are in the map.
- First posted on arXiv 5 Dec 2023.

## Builds on (most cited first, 6 of 6)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Deep physical neural networks enabled by a backpropagation algorithm for arbitrary physical systems](https://mlsanity.com/paper/2104.13386/) (2021)

## Abstract (arXiv)

Bone degradation, especially for astronauts in microgravity conditions, is crucial for space exploration missions since the lower applied external forces accelerate the diminution in bone stiffness and strength substantially. Although existing computational models help us understand this phenomenon and possibly restrict its effect in the future, they are time-consuming to simulate the changes in the bones, not just the bone microstructures, of each individual in detail. In this study, a robust yet fast computational method to predict and visualize bone degradation has been developed. Our deep-learning method, TransVNet, can take in different 3D voxelized images and predict their evolution throughout months utilizing a hybrid 3D-CNN-VisionTransformer autoencoder architecture. Because of limited available experimental data and challenges of obtaining new samples, a digital twin dataset of diverse and initial bone-like microstructures was generated to train our TransVNet on the evolution of the 3D images through a previously developed degradation model for microgravity.