# Learning Cortical Anomaly through Masked Encoding for Unsupervised Heterogeneity Mapping

arXiv: https://arxiv.org/abs/2312.02762 · HTML: https://mlsanity.com/paper/2312.02762/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 4 of its 23 references that are in the map.
- First posted on arXiv 5 Dec 2023.

## Builds on (most cited first, 4 of 4)

- [SimMIM: A Simple Framework for Masked Image Modeling](https://mlsanity.com/paper/2111.09886/) (2021)
- [ECOD: Unsupervised Outlier Detection Using Empirical Cumulative Distribution Functions](https://mlsanity.com/paper/2201.00382/) (2022)
- [Surface Vision Transformers: Attention-Based Modelling applied to Cortical Analysis](https://mlsanity.com/paper/2203.16414/) (2022)
- [Unsupervised anomaly localization using VAE and beta-VAE](https://mlsanity.com/paper/2005.10686/) (2020)

## Built on by (most cited first, 1 of 1)

- [Self-Supervised Masked Mesh Learning for Unsupervised Anomaly Detection on 3D Cortical Surfaces](https://mlsanity.com/paper/2412.05580/) (2024)

## Abstract (arXiv)

The detection of heterogeneous mental disorders based on brain readouts remains challenging due to the complexity of symptoms and the absence of reliable biomarkers. This paper introduces CAM (Cortical Anomaly Detection through Masked Image Modeling), a novel self-supervised framework designed for the unsupervised detection of complex brain disorders using cortical surface features. We employ this framework for the detection of individuals on the psychotic spectrum and demonstrate its capabilities compared to state-of-the-art methods, achieving an AUC of 0.696 for Schizoaffective and 0.769 for Schizophreniform, without the need for any labels. Furthermore, the analysis of atypical cortical regions, including Pars Triangularis and several frontal areas often implicated in schizophrenia, provides further confidence in our approach. Altogether, we demonstrate a scalable approach for anomaly detection of complex brain disorders based on cortical abnormalities. The code will be made available at https://github.com/chadHGY/CAM.