# The Importance of Downstream Networks in Digital Pathology Foundation Models

arXiv: https://arxiv.org/abs/2311.17804 · HTML: https://mlsanity.com/paper/2311.17804/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 22 references that are in the map.
- First posted on arXiv 29 Nov 2023.

## Builds on (most cited first, 16 of 16)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [Accurate, Large Minibatch SGD: Training ImageNet in 1 Hour](https://mlsanity.com/paper/1706.02677/) (2017)
- [Big Self-Supervised Models are Strong Semi-Supervised Learners](https://mlsanity.com/paper/2006.10029/) (2020)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [iBOT: Image BERT Pre-Training with Online Tokenizer](https://mlsanity.com/paper/2111.07832/) (2021)
- [Nystr"omformer: A Nystr"om-Based Algorithm for Approximating Self-Attention](https://mlsanity.com/paper/2102.03902/) (2021)
- [Benchmarking Self-Supervised Learning on Diverse Pathology Datasets](https://mlsanity.com/paper/2212.04690/) (2022)
- [Virchow: A Million-Slide Digital Pathology Foundation Model](https://mlsanity.com/paper/2309.07778/) (2023)
- [Multiple Instance Learning for Digital Pathology: A Review on the State-of-the-Art, Limitations & Future Potential](https://mlsanity.com/paper/2206.04425/) (2022)
- [A General-Purpose Self-Supervised Model for Computational Pathology](https://mlsanity.com/paper/2308.15474/) (2023)
- [HEROHE Challenge: assessing HER2 status in breast cancer without immunohistochemistry or in situ hybridization](https://mlsanity.com/paper/2111.04738/) (2021)

## Built on by (most cited first, 3 of 3)

- [PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology](https://mlsanity.com/paper/2405.10254/) (2024)
- [Rethinking Attention-Based Multiple Instance Learning for Whole-Slide Pathological Image Classification: An Instance Attribute Viewpoint](https://mlsanity.com/paper/2404.00351/) (2024)
- [Characterizing the Interpretability of Attention Maps in Digital Pathology](https://mlsanity.com/paper/2407.02484/) (2024)

## Abstract (arXiv)

Digital pathology has significantly advanced disease detection and pathologist efficiency through the analysis of gigapixel whole-slide images (WSI). In this process, WSIs are first divided into patches, for which a feature extractor model is applied to obtain feature vectors, which are subsequently processed by an aggregation model to predict the respective WSI label. With the rapid evolution of representation learning, numerous new feature extractor models, often termed foundational models, have emerged. Traditional evaluation methods rely on a static downstream aggregation model setup, encompassing a fixed architecture and hyperparameters, a practice we identify as potentially biasing the results. Our study uncovers a sensitivity of feature extractor models towards aggregation model configurations, indicating that performance comparability can be skewed based on the chosen configurations. By accounting for this sensitivity, we find that the performance of many current feature extractor models is notably similar. We support this insight by evaluating seven feature extractor models across three different datasets with 162 different aggregation model configurations. This comprehensive approach provides a more nuanced understanding of the feature extractors' sensitivity to various aggregation model configurations, leading to a fairer and more accurate assessment of new foundation models in digital pathology.