# Self-supervised OCT Image Denoising with Slice-to-Slice Registration and Reconstruction

arXiv: https://arxiv.org/abs/2311.15167 · HTML: https://mlsanity.com/paper/2311.15167/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 14 references that are in the map.
- First posted on arXiv 26 Nov 2023.

## Builds on (most cited first, 6 of 6)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Neighbor2Neighbor: Self-Supervised Denoising from Single Noisy Images](https://mlsanity.com/paper/2101.02824/) (2021)
- [Self-supervised Denoising via Diffeomorphic Template Estimation: Application to Optical Coherence Tomography](https://mlsanity.com/paper/2008.08024/) (2020)

## Abstract (arXiv)

Strong speckle noise is inherent to optical coherence tomography (OCT) imaging and represents a significant obstacle for accurate quantitative analysis of retinal structures which is key for advances in clinical diagnosis and monitoring of disease. Learning-based self-supervised methods for structure-preserving noise reduction have demonstrated superior performance over traditional methods but face unique challenges in OCT imaging. The high correlation of voxels generated by coherent A-scan beams undermines the efficacy of self-supervised learning methods as it violates the assumption of independent pixel noise. We conduct experiments demonstrating limitations of existing models due to this independence assumption. We then introduce a new end-to-end self-supervised learning framework specifically tailored for OCT image denoising, integrating slice-by-slice training and registration modules into one network. An extensive ablation study is conducted for the proposed approach. Comparison to previously published self-supervised denoising models demonstrates improved performance of the proposed framework, potentially serving as a preprocessing step towards superior segmentation performance and quantitative analysis.