# Selection of Distinct Morphologies to Divide & Conquer Gigapixel Pathology Images

arXiv: https://arxiv.org/abs/2311.09902 · HTML: https://mlsanity.com/paper/2311.09902/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 30 of its 51 references that are in the map.
- First posted on arXiv 16 Nov 2023.

## Builds on (most cited first, 30 of 30)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [Aggregated Residual Transformations for Deep Neural Networks](https://mlsanity.com/paper/1611.05431/) (2016)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Fine-tuning CNN Image Retrieval with No Human Annotation](https://mlsanity.com/paper/1711.02512/) (2017)
- [BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images](https://mlsanity.com/paper/2111.04740/) (2021)
- [A Decade Survey of Content Based Image Retrieval using Deep Learning](https://mlsanity.com/paper/2012.00641/) (2020)
- [Cluster-to-Conquer: A Framework for End-to-End Multi-Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2103.10626/) (2021)
- [Fine-Tuning and Training of DenseNet for Histopathology Image Representation Using TCGA Diagnostic Slides](https://mlsanity.com/paper/2101.07903/) (2021)
- [Similar Image Search for Histopathology: SMILY](https://mlsanity.com/paper/1901.11112/) (2019)
- [Yottixel -- An Image Search Engine for Large Archives of Histopathology Whole Slide Images](https://mlsanity.com/paper/1911.08748/) (2019)
- [Representation Learning of Histopathology Images using Graph Neural Networks](https://mlsanity.com/paper/2004.07399/) (2020)
- [Pan-Cancer Diagnostic Consensus Through Searching Archival Histopathology Images Using Artificial Intelligence](https://mlsanity.com/paper/1911.08736/) (2019)
- [Learning to Predict RNA Sequence Expressions from Whole Slide Images with Applications for Search and Classification](https://mlsanity.com/paper/2203.13997/) (2022)
- [ScanNet: A Fast and Dense Scanning Framework for Metastatic Breast Cancer Detection from Whole-Slide Images](https://mlsanity.com/paper/1707.09597/) (2017)
- [MinMax Radon Barcodes for Medical Image Retrieval](https://mlsanity.com/paper/1610.00318/) (2016)
- [Learning Binary and Sparse Permutation-Invariant Representations for Fast and Memory Efficient Whole Slide Image Search](https://mlsanity.com/paper/2208.13653/) (2022)
- [Automatic Multi-Stain Registration of Whole Slide Images in Histopathology](https://mlsanity.com/paper/2107.14292/) (2021)
- [Comments on 'Fast and scalable search of whole-slide images via self-supervised deep learning'](https://mlsanity.com/paper/2304.08297/) (2023)
- [A Comparative Study of U-Net Topologies for Background Removal in Histopathology Images](https://mlsanity.com/paper/2006.06531/) (2020)
- [Ranking Loss and Sequestering Learning for Reducing Image Search Bias in Histopathology](https://mlsanity.com/paper/2304.08498/) (2023)
- [A Preliminary Investigation into Search and Matching for Tumour Discrimination in WHO Breast Taxonomy Using Deep Networks](https://mlsanity.com/paper/2308.11162/) (2023)
- [Immunohistochemistry Biomarkers-Guided Image Search for Histopathology](https://mlsanity.com/paper/2304.12424/) (2023)

## Built on by (most cited first, 2 of 2)

- [A Short Survey on Set-Based Aggregation Techniques for Single-Vector WSI Representation in Digital Pathology](https://mlsanity.com/paper/2409.04615/) (2024)
- [Reducing Redundancy in Whole-Slide Image Patching for Scalable Indexing and Retrieval](https://mlsanity.com/paper/2606.26157/) (2026)

## Abstract (arXiv)

Whole slide images (WSIs) are massive digital pathology files illustrating intricate tissue structures. Selecting a small, representative subset of patches from each WSI is essential yet challenging. Therefore, following the "Divide & Conquer" approach becomes essential to facilitate WSI analysis including the classification and the WSI matching in computational pathology. To this end, we propose a novel method termed "Selection of Distinct Morphologies" (SDM) to choose a subset of WSI patches. The aim is to encompass all inherent morphological variations within a given WSI while simultaneously minimizing the number of selected patches to represent these variations, ensuring a compact yet comprehensive set of patches. This systematically curated patch set forms what we term a "montage". We assess the representativeness of the SDM montage across various public and private histopathology datasets. This is conducted by using the leave-one-out WSI search and matching evaluation method, comparing it with the state-of-the-art Yottixel's mosaic. SDM demonstrates remarkable efficacy across all datasets during its evaluation. Furthermore, SDM eliminates the necessity for empirical parameterization, a crucial aspect of Yottixel's mosaic, by inherently optimizing the selection process to capture the distinct morphological features within the WSI.