# Exploring the Efficacy of Base Data Augmentation Methods in Deep Learning-Based Radiograph Classification of Knee Joint Osteoarthritis

arXiv: https://arxiv.org/abs/2311.06118 · HTML: https://mlsanity.com/paper/2311.06118/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 56 references that are in the map.
- First posted on arXiv 10 Nov 2023.

## Builds on (most cited first, 13 of 13)

- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [EfficientNetV2: Smaller Models and Faster Training](https://mlsanity.com/paper/2104.00298/) (2021)
- [Confounding variables can degrade generalization performance of radiological deep learning models](https://mlsanity.com/paper/1807.00431/) (2018)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks](https://mlsanity.com/paper/1807.10225/) (2018)
- [Differentially Private Synthetic Medical Data Generation using Convolutional GANs](https://mlsanity.com/paper/2012.11774/) (2020)
- [Automatic Knee Osteoarthritis Diagnosis from Plain Radiographs: A Deep Learning-Based Approach](https://mlsanity.com/paper/1710.10589/) (2017)
- [How to Fool Radiologists with Generative Adversarial Networks? A Visual Turing Test for Lung Cancer Diagnosis](https://mlsanity.com/paper/1710.09762/) (2017)
- [Multimodal Machine Learning-based Knee Osteoarthritis Progression Prediction from Plain Radiographs and Clinical Data](https://mlsanity.com/paper/1904.06236/) (2019)
- [Automatic Grading of Individual Knee Osteoarthritis Features in Plain Radiographs using Deep Convolutional Neural Networks](https://mlsanity.com/paper/1907.08020/) (2019)
- [Improving Performance in Colorectal Cancer Histology Decomposition using Deep and Ensemble Machine Learning](https://mlsanity.com/paper/2310.16954/) (2023)

## Built on by (most cited first, 3 of 3)

- [Identity-Consistent Diffusion Network for Grading Knee Osteoarthritis Progression in Radiographic Imaging](https://mlsanity.com/paper/2407.21381/) (2024)
- [Deep Fast Machine Learning Utils: A Python Library for Streamlined Machine Learning Prototyping](https://mlsanity.com/paper/2409.09537/) (2024)
- [PSSF: Early osteoarthritis detection using physical synthetic knee X-ray scans and AI radiomics models](https://mlsanity.com/paper/2601.11642/) (2026)

## Abstract (arXiv)

Diagnosing knee joint osteoarthritis (KOA), a major cause of disability worldwide, is challenging due to subtle radiographic indicators and the varied progression of the disease. Using deep learning for KOA diagnosis requires broad, comprehensive datasets. However, obtaining these datasets poses significant challenges due to patient privacy concerns and data collection restrictions. Additive data augmentation, which enhances data variability, emerges as a promising solution. Yet, it's unclear which augmentation techniques are most effective for KOA. This study explored various data augmentation methods, including adversarial augmentations, and their impact on KOA classification model performance. While some techniques improved performance, others commonly used underperformed. We identified potential confounding regions within the images using adversarial augmentation. This was evidenced by our models' ability to classify KL0 and KL4 grades accurately, with the knee joint omitted. This observation suggested a model bias, which might leverage unrelated features for classification currently present in radiographs. Interestingly, removing the knee joint also led to an unexpected improvement in KL1 classification accuracy. To better visualize these paradoxical effects, we employed Grad-CAM, highlighting the associated regions. Our study underscores the need for careful technique selection for improved model performance and identifying and managing potential confounding regions in radiographic KOA deep learning.