# Polar-Net: A Clinical-Friendly Model for Alzheimer's Disease Detection in OCTA Images

arXiv: https://arxiv.org/abs/2311.06009 · HTML: https://mlsanity.com/paper/2311.06009/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 25 references that are in the map.
- First posted on arXiv 10 Nov 2023.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [CBAM: Convolutional Block Attention Module](https://mlsanity.com/paper/1807.06521/) (2018)
- [Swin Transformer V2: Scaling Up Capacity and Resolution](https://mlsanity.com/paper/2111.09883/) (2021)
- [Visual Attention Network](https://mlsanity.com/paper/2202.09741/) (2022)
- [HorNet: Efficient High-Order Spatial Interactions with Recursive Gated Convolutions](https://mlsanity.com/paper/2207.14284/) (2022)
- [ROSE: A Retinal OCT-Angiography Vessel Segmentation Dataset and New Model](https://mlsanity.com/paper/2007.05201/) (2020)
- [Joint Optic Disc and Cup Segmentation Based on Multi-label Deep Network and Polar Transformation](https://mlsanity.com/paper/1801.00926/) (2018)
- [Retinal Structure Detection in OCTA Image via Voting-based Multi-task Learning](https://mlsanity.com/paper/2208.10745/) (2022)

## Built on by (most cited first, 2 of 2)

- [JointViT: Modeling Oxygen Saturation Levels with Joint Supervision on Long-Tailed OCTA](https://mlsanity.com/paper/2404.11525/) (2024)
- [VAMPIRE: Uncovering Vessel Directional and Morphological Information from OCTA Images for Cardiovascular Disease Risk Factor Prediction](https://mlsanity.com/paper/2507.20017/) (2025)

## Abstract (arXiv)

Optical Coherence Tomography Angiography (OCTA) is a promising tool for detecting Alzheimer's disease (AD) by imaging the retinal microvasculature. Ophthalmologists commonly use region-based analysis, such as the ETDRS grid, to study OCTA image biomarkers and understand the correlation with AD. However, existing studies have used general deep computer vision methods, which present challenges in providing interpretable results and leveraging clinical prior knowledge. To address these challenges, we propose a novel deep-learning framework called Polar-Net. Our approach involves mapping OCTA images from Cartesian coordinates to polar coordinates, which allows for the use of approximate sector convolution and enables the implementation of the ETDRS grid-based regional analysis method commonly used in clinical practice. Furthermore, Polar-Net incorporates clinical prior information of each sector region into the training process, which further enhances its performance. Additionally, our framework adapts to acquire the importance of the corresponding retinal region, which helps researchers and clinicians understand the model's decision-making process in detecting AD and assess its conformity to clinical observations. Through evaluations on private and public datasets, we have demonstrated that Polar-Net outperforms existing state-of-the-art methods and provides more valuable pathological evidence for the association between retinal vascular changes and AD. In addition, we also show that the two innovative modules introduced in our framework have a significant impact on improving overall performance.