# Using ResNet to Utilize 4-class T2-FLAIR Slice Classification Based on the Cholinergic Pathways Hyperintensities Scale for Pathological Aging

arXiv: https://arxiv.org/abs/2311.05477 · HTML: https://mlsanity.com/paper/2311.05477/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 1 of its 6 references that are in the map.
- First posted on arXiv 9 Nov 2023.

## Builds on (most cited first, 1 of 1)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)

## Abstract (arXiv)

The Cholinergic Pathways Hyperintensities Scale (CHIPS) is a visual rating scale used to assess the extent of cholinergic white matter hyperintensities in T2-FLAIR images, serving as an indicator of dementia severity. However, the manual selection of four specific slices for rating throughout the entire brain is a time-consuming process. Our goal was to develop a deep learning-based model capable of automatically identifying the four slices relevant to CHIPS. To achieve this, we trained a 4-class slice classification model (BSCA) using the ADNI T2-FLAIR dataset (N=150) with the assistance of ResNet. Subsequently, we tested the model's performance on a local dataset (N=30). The results demonstrated the efficacy of our model, with an accuracy of 99.82% and an F1-score of 99.83%. This achievement highlights the potential impact of BSCA as an automatic screening tool, streamlining the selection of four specific T2-FLAIR slices that encompass white matter landmarks along the cholinergic pathways. Clinicians can leverage this tool to assess the risk of clinical dementia development efficiently.