# Continuous Training and Fine-tuning for Domain-Specific Language Models in Medical Question Answering

arXiv: https://arxiv.org/abs/2311.00204 · HTML: https://mlsanity.com/paper/2311.00204/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 24 of its 34 references that are in the map.
- First posted on arXiv 1 Nov 2023.

## Builds on (most cited first, 24 of 24)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [Training Compute-Optimal Large Language Models](https://mlsanity.com/paper/2203.15556/) (2022)
- [A Survey of Large Language Models](https://mlsanity.com/paper/2303.18223/) (2023)
- [Don't Stop Pretraining: Adapt Language Models to Domains and Tasks](https://mlsanity.com/paper/2004.10964/) (2020)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [Adafactor: Adaptive Learning Rates with Sublinear Memory Cost](https://mlsanity.com/paper/1804.04235/) (2018)
- [Training Deep Nets with Sublinear Memory Cost](https://mlsanity.com/paper/1604.06174/) (2016)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [Continual Pre-Training of Large Language Models: How to (re)warm your model?](https://mlsanity.com/paper/2308.04014/) (2023)
- [Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Dataset](https://mlsanity.com/paper/2306.03030/) (2023)
- [A Brief Report on LawGPT 1.0: A Virtual Legal Assistant Based on GPT-3](https://mlsanity.com/paper/2302.05729/) (2023)
- [Huatuo-26M, a Large-scale Chinese Medical QA Dataset](https://mlsanity.com/paper/2305.01526/) (2023)
- [CSL: A Large-scale Chinese Scientific Literature Dataset](https://mlsanity.com/paper/2209.05034/) (2022)
- [Continual Training of Language Models for Few-Shot Learning](https://mlsanity.com/paper/2210.05549/) (2022)
- [GreenPLM: Cross-Lingual Transfer of Monolingual Pre-Trained Language Models at Almost No Cost](https://mlsanity.com/paper/2211.06993/) (2022)

## Built on by (most cited first, 4 of 4)

- [Continual Learning of Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2404.16789/) (2024)
- [Large Language Models in Mental Health Care: a Scoping Review](https://mlsanity.com/paper/2401.02984/) (2024)
- [When Continue Learning Meets Multimodal Large Language Model: A Survey](https://mlsanity.com/paper/2503.01887/) (2025)
- [Continual Pre-Training is (not) What You Need in Domain Adaption](https://mlsanity.com/paper/2504.13603/) (2025)

## Abstract (arXiv)

Large language models exhibit promising general capabilities but often lack specialized knowledge for domain-specific tasks. Developing domain experts from a base model enables a range of applications without prohibitive training costs. This work demonstrates a method using continuous training and instruction fine-tuning to rapidly adapt Llama 2 base models to the Chinese medical domain. We first conduct continuous training on 1B tokens from Chinese medical references to teach relevant vocabulary and knowledge. The models are then fine-tuned on 54K examples sourced from the Chinese National Medical Licensing Examination. Experiments on Chinese medical data confirm the effectiveness of this approach, producing a model comparable to GPT-3.5-turbo while using way less computational resource. The resulting domain-specific model could be useful for various Chinese medical applications. More broadly, this provides a template for domain-specific training of large language models in areas where pre-trained models lack the required expertise, such as law, science, and engineering.