# SC-MIL: Sparsely Coded Multiple Instance Learning for Whole Slide Image Classification

arXiv: https://arxiv.org/abs/2311.00048 · HTML: https://mlsanity.com/paper/2311.00048/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Builds on 24 of its 50 references that are in the map.
- First posted on arXiv 31 Oct 2023.

## Builds on (most cited first, 24 of 24)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Non-local Neural Networks](https://mlsanity.com/paper/1711.07971/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [Coordinate Descent Algorithms](https://mlsanity.com/paper/1502.04759/) (2015)
- [Asymmetric Non-local Neural Networks for Semantic Segmentation](https://mlsanity.com/paper/1908.07678/) (2019)
- [Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification](https://mlsanity.com/paper/1504.07947/) (2015)
- [Revisiting Multiple Instance Neural Networks](https://mlsanity.com/paper/1610.02501/) (2016)
- [Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Images](https://mlsanity.com/paper/2303.06873/) (2023)
- [CAMEL: A Weakly Supervised Learning Framework for Histopathology Image Segmentation](https://mlsanity.com/paper/1908.10555/) (2019)
- [Cluster-to-Conquer: A Framework for End-to-End Multi-Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2103.10626/) (2021)
- [Task-specific Fine-tuning via Variational Information Bottleneck for Weakly-supervised Pathology Whole Slide Image Classification](https://mlsanity.com/paper/2303.08446/) (2023)
- [Weakly supervised multiple instance learning histopathological tumor segmentation](https://mlsanity.com/paper/2004.05024/) (2020)
- [Semi-Supervised Histology Classification using Deep Multiple Instance Learning and Contrastive Predictive Coding](https://mlsanity.com/paper/1910.10825/) (2019)
- [Deep Multi-instance Networks with Sparse Label Assignment for Whole Mammogram Classification](https://mlsanity.com/paper/1612.05968/) (2016)
- [Deep K-SVD Denoising](https://mlsanity.com/paper/1909.13164/) (2019)
- [Multiple instance learning with graph neural networks](https://mlsanity.com/paper/1906.04881/) (2019)
- [A Comprehensive Review for Breast Histopathology Image Analysis Using Classical and Deep Neural Networks](https://mlsanity.com/paper/2003.12255/) (2020)
- [Revisiting Sparse Convolutional Model for Visual Recognition](https://mlsanity.com/paper/2210.12945/) (2022)

## Built on by (most cited first, 6 of 6)

- [DGR-MIL: Exploring Diverse Global Representation in Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2407.03575/) (2024)
- [TimeMIL: Advancing Multivariate Time Series Classification via a Time-aware Multiple Instance Learning](https://mlsanity.com/paper/2405.03140/) (2024)
- [How Effective Can Dropout Be in Multiple Instance Learning ?](https://mlsanity.com/paper/2504.14783/) (2025)
- [Cracking Instance Jigsaw Puzzles: An Alternative to Multiple Instance Learning for Whole Slide Image Analysis](https://mlsanity.com/paper/2507.08178/) (2025)
- [Towards Privacy-Preserving Fine-Grained Visual Classification via Hierarchical Learning from Label Proportions](https://mlsanity.com/paper/2505.23031/) (2025)
- [Nonparametric Distribution Matching for Self-Supervised Whole-Slide Image Condensation](https://mlsanity.com/paper/2610.00678/) (2026)

## Abstract (arXiv)

Multiple Instance Learning (MIL) has been widely used in weakly supervised whole slide image (WSI) classification. Typical MIL methods include a feature embedding part, which embeds the instances into features via a pre-trained feature extractor, and an MIL aggregator that combines instance embeddings into predictions. Most efforts have typically focused on improving these parts. This involves refining the feature embeddings through self-supervised pre-training as well as modeling the correlations between instances separately. In this paper, we proposed a sparsely coding MIL (SC-MIL) method that addresses those two aspects at the same time by leveraging sparse dictionary learning. The sparse dictionary learning captures the similarities of instances by expressing them as sparse linear combinations of atoms in an over-complete dictionary. In addition, imposing sparsity improves instance feature embeddings by suppressing irrelevant instances while retaining the most relevant ones. To make the conventional sparse coding algorithm compatible with deep learning, we unrolled it into a sparsely coded module leveraging deep unrolling. The proposed SC module can be incorporated into any existing MIL framework in a plug-and-play manner with an acceptable computational cost. The experimental results on multiple datasets demonstrated that the proposed SC module could substantially boost the performance of state-of-the-art MIL methods. The codes are available at hrefhttps://github.com/sotiraslab/SCMIL.githttps://github.com/sotiraslab/SCMIL.git.