# Medical Image Denosing via Explainable AI Feature Preserving Loss

arXiv: https://arxiv.org/abs/2310.20101 · HTML: https://mlsanity.com/paper/2310.20101/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 24 references that are in the map.
- First posted on arXiv 31 Oct 2023.

## Builds on (most cited first, 11 of 11)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [SmoothGrad: removing noise by adding noise](https://mlsanity.com/paper/1706.03825/) (2017)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [Plug-and-Play Image Restoration with Deep Denoiser Prior](https://mlsanity.com/paper/2008.13751/) (2020)
- [Explainable artificial intelligence (XAI) in deep learning-based medical image analysis](https://mlsanity.com/paper/2107.10912/) (2021)
- [CVF-SID: Cyclic multi-Variate Function for Self-Supervised Image Denoising by Disentangling Noise from Image](https://mlsanity.com/paper/2203.13009/) (2022)

## Built on by (most cited first, 1 of 1)

- [A Novel Context-Adaptive Fusion of Shadow and Highlight Regions for Efficient Sonar Image Classification](https://mlsanity.com/paper/2506.01445/) (2025)

## Abstract (arXiv)

Denoising algorithms play a crucial role in medical image processing and analysis. However, classical denoising algorithms often ignore explanatory and critical medical features preservation, which may lead to misdiagnosis and legal liabilities. In this work, we propose a new denoising method for medical images that not only efficiently removes various types of noise, but also preserves key medical features throughout the process. To achieve this goal, we utilize a gradient-based eXplainable Artificial Intelligence (XAI) approach to design a feature preserving loss function. Our feature preserving loss function is motivated by the characteristic that gradient-based XAI is sensitive to noise. Through backpropagation, medical image features before and after denoising can be kept consistent. We conducted extensive experiments on three available medical image datasets, including synthesized 13 different types of noise and artifacts. The experimental results demonstrate the superiority of our method in terms of denoising performance, model explainability, and generalization.