# DiffBoost: Enhancing Medical Image Segmentation via Text-Guided Diffusion Model

arXiv: https://arxiv.org/abs/2310.12868 · HTML: https://mlsanity.com/paper/2310.12868/

## Key facts

- Cited by 23 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 42 of its 58 references that are in the map.
- First posted on arXiv 19 Oct 2023.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 42)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Explaining and Harnessing Adversarial Examples](https://mlsanity.com/paper/1412.6572/) (2014)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [InstructPix2Pix: Learning to Follow Image Editing Instructions](https://mlsanity.com/paper/2211.09800/) (2022)
- [RandAugment: Practical automated data augmentation with a reduced search space](https://mlsanity.com/paper/1909.13719/) (2019)
- [An Image is Worth One Word: Personalizing Text-to-Image Generation using Textual Inversion](https://mlsanity.com/paper/2208.01618/) (2022)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [Holistically-Nested Edge Detection](https://mlsanity.com/paper/1504.06375/) (2015)
- [Label-Efficient Semantic Segmentation with Diffusion Models](https://mlsanity.com/paper/2112.03126/) (2021)
- [MONAI: An open-source framework for deep learning in healthcare](https://mlsanity.com/paper/2211.02701/) (2022)
- [Open-Vocabulary Panoptic Segmentation with Text-to-Image Diffusion Models](https://mlsanity.com/paper/2303.04803/) (2023)
- [Diffusion Models for Medical Anomaly Detection](https://mlsanity.com/paper/2203.04306/) (2022)
- [TrivialAugment: Tuning-free Yet State-of-the-Art Data Augmentation](https://mlsanity.com/paper/2103.10158/) (2021)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks](https://mlsanity.com/paper/1807.10225/) (2018)
- [MedSegDiff-V2: Diffusion based Medical Image Segmentation with Transformer](https://mlsanity.com/paper/2301.11798/) (2023)
- [Ambiguous Medical Image Segmentation using Diffusion Models](https://mlsanity.com/paper/2304.04745/) (2023)
- [Conditional Diffusion Models for Semantic 3D Brain MRI Synthesis](https://mlsanity.com/paper/2305.18453/) (2023)
- [Conversion Between CT and MRI Images Using Diffusion and Score-Matching Models](https://mlsanity.com/paper/2209.12104/) (2022)

## Built on by (most cited first, 23 of 23)

- [Image Segmentation in Foundation Model Era: A Survey](https://mlsanity.com/paper/2408.12957/) (2024)
- [MedSegFactory: Text-Guided Generation of Medical Image-Mask Pairs](https://mlsanity.com/paper/2504.06897/) (2025)
- [Regression is all you need for medical image translation](https://mlsanity.com/paper/2505.02048/) (2025)
- [MedEBench: Diagnosing Reliability in Text-Guided Medical Image Editing](https://mlsanity.com/paper/2506.01921/) (2025)
- [Deformation-Recovery Diffusion Model (DRDM): Instance Deformation for Image Manipulation and Synthesis](https://mlsanity.com/paper/2407.07295/) (2024)
- [MedDiff-FM: A Diffusion-based Foundation Model for Versatile Medical Image Applications](https://mlsanity.com/paper/2410.15432/) (2024)
- [Prompt to Polyp: Medical Text-Conditioned Image Synthesis with Diffusion Models](https://mlsanity.com/paper/2505.05573/) (2025)
- [Ctrl-GenAug: Controllable Generative Augmentation for Medical Sequence Classification](https://mlsanity.com/paper/2409.17091/) (2024)
- [Denoising Diffusion Models for Anomaly Localization in Medical Images](https://mlsanity.com/paper/2410.23834/) (2024)
- [ImmunoDiff: A Diffusion Model for Immunotherapy Response Prediction in Lung Cancer](https://mlsanity.com/paper/2505.23675/) (2025)
- [REN: Anatomically-Informed Mixture-of-Experts for Interstitial Lung Disease Diagnosis](https://mlsanity.com/paper/2510.04923/) (2025)
- [Generative Drifting for Conditional Medical Image Generation](https://mlsanity.com/paper/2604.19736/) (2026)
- [Boosting 3D Liver Shape Datasets with Diffusion Models and Implicit Neural Representations](https://mlsanity.com/paper/2504.19402/) (2025)
- [T2I-ConBench: Text-to-Image Benchmark for Continual Post-training](https://mlsanity.com/paper/2505.16875/) (2025)
- [Discrete Diffusion Models with MLLMs for Unified Medical Multimodal Generation](https://mlsanity.com/paper/2510.06131/) (2025)
- [IgCONDA-PET: Weakly-Supervised PET Anomaly Detection using Implicitly-Guided Attention-Conditional Counterfactual Diffusion Modeling -- a Multi-Center, Multi-Cancer, and Multi-Tracer Study](https://mlsanity.com/paper/2405.00239/) (2024)
- [Federated Breast Cancer Detection Enhanced by Synthetic Ultrasound Image Augmentation](https://mlsanity.com/paper/2506.23334/) (2025)
- [IELDG: Suppressing Domain-Specific Noise with Inverse Evolution Layers for Domain Generalized Semantic Segmentation](https://mlsanity.com/paper/2508.19604/) (2025)
- [AURAD: Anatomy-Pathology Unified Radiology Synthesis with Progressive Representations](https://mlsanity.com/paper/2509.04819/) (2025)
- [BrainNormalizer: Anatomy-Informed Pseudo-Healthy Brain Reconstruction from Tumor MRI via Edge-Guided ControlNet](https://mlsanity.com/paper/2511.12853/) (2025)
- [PromptMAD: Cross-Modal Prompting for Multi-Class Visual Anomaly Localization](https://mlsanity.com/paper/2601.22492/) (2026)
- [Layout-Guided Controllable Pathology Image Generation with In-Context Diffusion Transformers](https://mlsanity.com/paper/2603.13386/) (2026)
- [OTLesMix: Wasserstein Barycenter and Optimal Transport Map for Synthetic Lesion Generation with Diverse Shapes and Locations](https://mlsanity.com/paper/2608.06264/) (2026)

## Abstract (arXiv)

Large-scale, big-variant, high-quality data are crucial for developing robust and successful deep-learning models for medical applications since they potentially enable better generalization performance and avoid overfitting. However, the scarcity of high-quality labeled data always presents significant challenges. This paper proposes a novel approach to address this challenge by developing controllable diffusion models for medical image synthesis, called DiffBoost. We leverage recent diffusion probabilistic models to generate realistic and diverse synthetic medical image data that preserve the essential characteristics of the original medical images by incorporating edge information of objects to guide the synthesis process. In our approach, we ensure that the synthesized samples adhere to medically relevant constraints and preserve the underlying structure of imaging data. Due to the random sampling process by the diffusion model, we can generate an arbitrary number of synthetic images with diverse appearances. To validate the effectiveness of our proposed method, we conduct an extensive set of medical image segmentation experiments on multiple datasets, including Ultrasound breast (+13.87%), CT spleen (+0.38%), and MRI prostate (+7.78%), achieving significant improvements over the baseline segmentation methods. The promising results demonstrate the effectiveness of our textcolorblackDiffBoost for medical image segmentation tasks and show the feasibility of introducing a first-ever text-guided diffusion model for general medical image segmentation tasks. With carefully designed ablation experiments, we investigate the influence of various data augmentations, hyper-parameter settings, patch size for generating random merging mask settings, and combined influence with different network architectures. Source code are available at https://github.com/NUBagciLab/DiffBoost.