# Super resolution of histopathological frozen sections via deep learning preserving tissue structure

arXiv: https://arxiv.org/abs/2310.11112 · HTML: https://mlsanity.com/paper/2310.11112/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 18 of its 36 references that are in the map.
- First posted on arXiv 17 Oct 2023.

## Builds on (most cited first, 18 of 18)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Perceptual Losses for Real-Time Style Transfer and Super-Resolution](https://mlsanity.com/paper/1603.08155/) (2016)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Image Super-Resolution Using Very Deep Residual Channel Attention Networks](https://mlsanity.com/paper/1807.02758/) (2018)
- [ESRGAN: Enhanced Super-Resolution Generative Adversarial Networks](https://mlsanity.com/paper/1809.00219/) (2018)
- [Real-ESRGAN: Training Real-World Blind Super-Resolution with Pure Synthetic Data](https://mlsanity.com/paper/2107.10833/) (2021)
- [The Perception-Distortion Tradeoff](https://mlsanity.com/paper/1711.06077/) (2017)
- [SRDiff: Single Image Super-Resolution with Diffusion Probabilistic Models](https://mlsanity.com/paper/2104.14951/) (2021)
- [Transformer for Single Image Super-Resolution](https://mlsanity.com/paper/2108.11084/) (2021)
- [Fourier Space Losses for Efficient Perceptual Image Super-Resolution](https://mlsanity.com/paper/2106.00783/) (2021)
- [Deep learning-based virtual histology staining using auto-fluorescence of label-free tissue](https://mlsanity.com/paper/1803.11293/) (2018)
- [Denoising Diffusion Probabilistic Models for Robust Image Super-Resolution in the Wild](https://mlsanity.com/paper/2302.07864/) (2023)
- [Robust Super-Resolution GAN, with Manifold-based and Perception Loss](https://mlsanity.com/paper/1903.06920/) (2019)

## Built on by (most cited first, 1 of 1)

- [CAFlow: Adaptive-Depth Single-Step Flow Matching for Efficient Histopathology Super-Resolution](https://mlsanity.com/paper/2603.18513/) (2026)

## Abstract (arXiv)

Histopathology plays a pivotal role in medical diagnostics. In contrast to preparing permanent sections for histopathology, a time-consuming process, preparing frozen sections is significantly faster and can be performed during surgery, where the sample scanning time should be optimized. Super-resolution techniques allow imaging the sample in lower magnification and sparing scanning time. In this paper, we present a new approach to super resolution for histopathological frozen sections, with focus on achieving better distortion measures, rather than pursuing photorealistic images that may compromise critical diagnostic information. Our deep-learning architecture focuses on learning the error between interpolated images and real images, thereby it generates high-resolution images while preserving critical image details, reducing the risk of diagnostic misinterpretation. This is done by leveraging the loss functions in the frequency domain, assigning higher weights to the reconstruction of complex, high-frequency components. In comparison to existing methods, we obtained significant improvements in terms of Structural Similarity Index (SSIM) and Peak Signal-to-Noise Ratio (PSNR), as well as indicated details that lost in the low-resolution frozen-section images, affecting the pathologist's clinical decisions. Our approach has a great potential in providing more-rapid frozen-section imaging, with less scanning, while preserving the high resolution in the imaged sample.