# Tertiary Lymphoid Structures Generation through Graph-based Diffusion

arXiv: https://arxiv.org/abs/2310.06661 · HTML: https://mlsanity.com/paper/2310.06661/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 13 of its 28 references that are in the map.
- First posted on arXiv 10 Oct 2023.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 13 of 13)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Structured Denoising Diffusion Models in Discrete State-Spaces](https://mlsanity.com/paper/2107.03006/) (2021)
- [DiGress: Discrete Denoising diffusion for graph generation](https://mlsanity.com/paper/2209.14734/) (2022)
- [Score-based Generative Modeling of Graphs via the System of Stochastic Differential Equations](https://mlsanity.com/paper/2202.02514/) (2022)
- [Permutation Invariant Graph Generation via Score-Based Generative Modeling](https://mlsanity.com/paper/2003.00638/) (2020)
- [Graph Representation Learning in Biomedicine](https://mlsanity.com/paper/2104.04883/) (2021)
- [Synthcity: facilitating innovative use cases of synthetic data in different data modalities](https://mlsanity.com/paper/2301.07573/) (2023)
- [A Morphology Focused Diffusion Probabilistic Model for Synthesis of Histopathology Images](https://mlsanity.com/paper/2209.13167/) (2022)
- [Diffusion Models for Graphs Benefit From Discrete State Spaces](https://mlsanity.com/paper/2210.01549/) (2022)
- [A Survey on Graph-Based Deep Learning for Computational Histopathology](https://mlsanity.com/paper/2107.00272/) (2021)
- [Quantifying Explainers of Graph Neural Networks in Computational Pathology](https://mlsanity.com/paper/2011.12646/) (2020)
- [HistoCartography: A Toolkit for Graph Analytics in Digital Pathology](https://mlsanity.com/paper/2107.10073/) (2021)

## Built on by (most cited first, 2 of 2)

- [Generative Modelling of Structurally Constrained Graphs](https://mlsanity.com/paper/2406.17341/) (2024)
- [Content Generation Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challenges](https://mlsanity.com/paper/2505.10993/) (2025)

## Abstract (arXiv)

Graph-based representation approaches have been proven to be successful in the analysis of biomedical data, due to their capability of capturing intricate dependencies between biological entities, such as the spatial organization of different cell types in a tumor tissue. However, to further enhance our understanding of the underlying governing biological mechanisms, it is important to accurately capture the actual distributions of such complex data. Graph-based deep generative models are specifically tailored to accomplish that. In this work, we leverage state-of-the-art graph-based diffusion models to generate biologically meaningful cell-graphs. In particular, we show that the adopted graph diffusion model is able to accurately learn the distribution of cells in terms of their tertiary lymphoid structures (TLS) content, a well-established biomarker for evaluating the cancer progression in oncology research. Additionally, we further illustrate the utility of the learned generative models for data augmentation in a TLS classification task. To the best of our knowledge, this is the first work that leverages the power of graph diffusion models in generating meaningful biological cell structures.