# A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics

arXiv: https://arxiv.org/abs/2310.05694 · HTML: https://mlsanity.com/paper/2310.05694/

## Key facts

- Cited by 163 papers in the map (data through 14 Oct 2026).
- Builds on 222 of its 421 references that are in the map.
- First posted on arXiv 9 Oct 2023.

## Builds on (most cited first, 30 of 222)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [BART: Denoising Sequence-to-Sequence Pre-training for Natural Language Generation, Translation, and Comprehension](https://mlsanity.com/paper/1910.13461/) (2019)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [Finetuned Language Models Are Zero-Shot Learners](https://mlsanity.com/paper/2109.01652/) (2021)
- [OPT: Open Pre-trained Transformer Language Models](https://mlsanity.com/paper/2205.01068/) (2022)
- [Gaussian Error Linear Units (GELUs)](https://mlsanity.com/paper/1606.08415/) (2016)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [Training Compute-Optimal Large Language Models](https://mlsanity.com/paper/2203.15556/) (2022)
- [ALBERT: A Lite BERT for Self-supervised Learning of Language Representations](https://mlsanity.com/paper/1909.11942/) (2019)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)

## Built on by (most cited first, 30 of 163)

- [A Survey on the Memory Mechanism of Large Language Model based Agents](https://mlsanity.com/paper/2404.13501/) (2024)
- [Stop Overthinking: A Survey on Efficient Reasoning for Large Language Models](https://mlsanity.com/paper/2503.16419/) (2025)
- [BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains](https://mlsanity.com/paper/2402.10373/) (2024)
- [Efficient Large Language Models: A Survey](https://mlsanity.com/paper/2312.03863/) (2023)
- [Mobile Edge Intelligence for Large Language Models: A Contemporary Survey](https://mlsanity.com/paper/2407.18921/) (2024)
- [Large language models in healthcare and medical domain: A review](https://mlsanity.com/paper/2401.06775/) (2023)
- [Vision-Language Models for Medical Report Generation and Visual Question Answering: A Review](https://mlsanity.com/paper/2403.02469/) (2024)
- [A Survey of Large Language Models in Medicine: Progress, Application, and Challenge](https://mlsanity.com/paper/2311.05112/) (2023)
- [Foundation Model for Advancing Healthcare: Challenges, Opportunities, and Future Directions](https://mlsanity.com/paper/2404.03264/) (2024)
- [Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Data](https://mlsanity.com/paper/2401.06866/) (2024)
- [A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine](https://mlsanity.com/paper/2405.08603/) (2024)
- [What is the Role of Small Models in the LLM Era: A Survey](https://mlsanity.com/paper/2409.06857/) (2024)
- [Are LLMs Ready for Real-World Materials Discovery?](https://mlsanity.com/paper/2402.05200/) (2024)
- [FiDeLiS: Faithful Reasoning in Large Language Model for Knowledge Graph Question Answering](https://mlsanity.com/paper/2405.13873/) (2024)
- [GEM: Empowering MLLM for Grounded ECG Understanding with Time Series and Images](https://mlsanity.com/paper/2503.06073/) (2025)
- [A Survey on Medical Large Language Models: Technology, Application, Trustworthiness, and Future Directions](https://mlsanity.com/paper/2406.03712/) (2024)
- [PoisonBench: Assessing Large Language Model Vulnerability to Data Poisoning](https://mlsanity.com/paper/2410.08811/) (2024)
- [Towards Trustworthy Retrieval Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2502.06872/) (2025)
- [WordGame: Efficient & Effective LLM Jailbreak via Simultaneous Obfuscation in Query and Response](https://mlsanity.com/paper/2405.14023/) (2024)
- [Navigating LLM Ethics: Advancements, Challenges, and Future Directions](https://mlsanity.com/paper/2406.18841/) (2024)
- [Data-Centric Foundation Models in Computational Healthcare: A Survey](https://mlsanity.com/paper/2401.02458/) (2024)
- [Can Knowledge Graphs Make Large Language Models More Trustworthy? An Empirical Study Over Open-ended Question Answering](https://mlsanity.com/paper/2410.08085/) (2024)
- [Harnessing Large Language Models for Knowledge Graph Question Answering via Adaptive Multi-Aspect Retrieval-Augmentation](https://mlsanity.com/paper/2412.18537/) (2024)
- [Towards Urban General Intelligence: A Review and Outlook of Urban Foundation Models](https://mlsanity.com/paper/2402.01749/) (2024)
- [T-RAG: Lessons from the LLM Trenches](https://mlsanity.com/paper/2402.07483/) (2024)
- [Attention Reallocation: Towards Zero-cost and Controllable Hallucination Mitigation of MLLMs](https://mlsanity.com/paper/2503.08342/) (2025)
- [Towards Trustworthy AI: A Review of Ethical and Robust Large Language Models](https://mlsanity.com/paper/2407.13934/) (2024)
- [TAID: Temporally Adaptive Interpolated Distillation for Efficient Knowledge Transfer in Language Models](https://mlsanity.com/paper/2501.16937/) (2025)
- [Representation Engineering for Large-Language Models: Survey and Research Challenges](https://mlsanity.com/paper/2502.17601/) (2025)
- [Aloe: A Family of Fine-tuned Open Healthcare LLMs](https://mlsanity.com/paper/2405.01886/) (2024)

## Abstract (arXiv)

The utilization of large language models (LLMs) in the Healthcare domain has generated both excitement and concern due to their ability to effectively respond to freetext queries with certain professional knowledge. This survey outlines the capabilities of the currently developed LLMs for Healthcare and explicates their development process, with the aim of providing an overview of the development roadmap from traditional Pretrained Language Models (PLMs) to LLMs. Specifically, we first explore the potential of LLMs to enhance the efficiency and effectiveness of various Healthcare applications highlighting both the strengths and limitations. Secondly, we conduct a comparison between the previous PLMs and the latest LLMs, as well as comparing various LLMs with each other. Then we summarize related Healthcare training data, training methods, optimization strategies, and usage. Finally, the unique concerns associated with deploying LLMs in Healthcare settings are investigated, particularly regarding fairness, accountability, transparency and ethics. Our survey provide a comprehensive investigation from perspectives of both computer science and Healthcare specialty. Besides the discussion about Healthcare concerns, we supports the computer science community by compiling a collection of open source resources, such as accessible datasets, the latest methodologies, code implementations, and evaluation benchmarks in the Github. Summarily, we contend that a significant paradigm shift is underway, transitioning from PLMs to LLMs. This shift encompasses a move from discriminative AI approaches to generative AI approaches, as well as a shift from model-centered methodologies to data-centered methodologies. Also, we determine that the biggest obstacle of using LLMs in Healthcare are fairness, accountability, transparency and ethics.