# CAMEL2: Enhancing weakly supervised learning for histopathology images by incorporating the significance ratio

arXiv: https://arxiv.org/abs/2310.05394 · HTML: https://mlsanity.com/paper/2310.05394/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 35 references that are in the map.
- First posted on arXiv 9 Oct 2023.

## Builds on (most cited first, 14 of 14)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Learning Pixel-level Semantic Affinity with Image-level Supervision for Weakly Supervised Semantic Segmentation](https://mlsanity.com/paper/1803.10464/) (2018)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [Object Region Mining with Adversarial Erasing: A Simple Classification to Semantic Segmentation Approach](https://mlsanity.com/paper/1703.08448/) (2017)
- [Weakly Supervised Deep Detection Networks](https://mlsanity.com/paper/1511.02853/) (2015)
- [Weakly Supervised Contrastive Learning](https://mlsanity.com/paper/2110.04770/) (2021)
- [CAMEL: A Weakly Supervised Learning Framework for Histopathology Image Segmentation](https://mlsanity.com/paper/1908.10555/) (2019)
- [Constrained Deep Weak Supervision for Histopathology Image Segmentation](https://mlsanity.com/paper/1701.00794/) (2017)
- [Weakly Supervised Deep Learning for COVID-19 Infection Detection and Classification from CT Images](https://mlsanity.com/paper/2004.06689/) (2020)
- [Label Cleaning Multiple Instance Learning: Refining Coarse Annotations on Single Whole-Slide Images](https://mlsanity.com/paper/2109.10778/) (2021)

## Abstract (arXiv)

Histopathology image analysis plays a crucial role in cancer diagnosis. However, training a clinically applicable segmentation algorithm requires pathologists to engage in labour-intensive labelling. In contrast, weakly supervised learning methods, which only require coarse-grained labels at the image level, can significantly reduce the labeling efforts. Unfortunately, while these methods perform reasonably well in slide-level prediction, their ability to locate cancerous regions, which is essential for many clinical applications, remains unsatisfactory. Previously, we proposed CAMEL, which achieves comparable results to those of fully supervised baselines in pixel-level segmentation. However, CAMEL requires 1,280x1,280 image-level binary annotations for positive WSIs. Here, we present CAMEL2, by introducing a threshold of the cancerous ratio for positive bags, it allows us to better utilize the information, consequently enabling us to scale up the image-level setting from 1,280x1,280 to 5,120x5,120 while maintaining the accuracy. Our results with various datasets, demonstrate that CAMEL2, with the help of 5,120x5,120 image-level binary annotations, which are easy to annotate, achieves comparable performance to that of a fully supervised baseline in both instance- and slide-level classifications.