# Whole Slide Multiple Instance Learning for Predicting Axillary Lymph Node Metastasis

arXiv: https://arxiv.org/abs/2310.04187 · HTML: https://mlsanity.com/paper/2310.04187/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 16 references that are in the map.
- First posted on arXiv 6 Oct 2023.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [RandAugment: Practical automated data augmentation with a reduced search space](https://mlsanity.com/paper/1909.13719/) (2019)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [AugMix: A Simple Data Processing Method to Improve Robustness and Uncertainty](https://mlsanity.com/paper/1912.02781/) (2019)
- [AutoAugment: Learning Augmentation Policies from Data](https://mlsanity.com/paper/1805.09501/) (2018)
- [TrivialAugment: Tuning-free Yet State-of-the-Art Data Augmentation](https://mlsanity.com/paper/2103.10158/) (2021)
- [Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides](https://mlsanity.com/paper/2112.02222/) (2021)
- [Quantifying Explainers of Graph Neural Networks in Computational Pathology](https://mlsanity.com/paper/2011.12646/) (2020)

## Abstract (arXiv)

Breast cancer is a major concern for women's health globally, with axillary lymph node (ALN) metastasis identification being critical for prognosis evaluation and treatment guidance. This paper presents a deep learning (DL) classification pipeline for quantifying clinical information from digital core-needle biopsy (CNB) images, with one step less than existing methods. A publicly available dataset of 1058 patients was used to evaluate the performance of different baseline state-of-the-art (SOTA) DL models in classifying ALN metastatic status based on CNB images. An extensive ablation study of various data augmentation techniques was also conducted. Finally, the manual tumor segmentation and annotation step performed by the pathologists was assessed.