# BTDNet: a Multi-Modal Approach for Brain Tumor Radiogenomic Classification

arXiv: https://arxiv.org/abs/2310.03485 · HTML: https://mlsanity.com/paper/2310.03485/

## Key facts

- Cited by 20 papers in the map (data through 14 Oct 2026).
- Builds on 27 of its 56 references that are in the map.
- First posted on arXiv 5 Oct 2023.

## Builds on (most cited first, 27 of 27)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [Gaussian Error Linear Units (GELUs)](https://mlsanity.com/paper/1606.08415/) (2016)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [How Does Batch Normalization Help Optimization?](https://mlsanity.com/paper/1805.11604/) (2018)
- [Expression, Affect, Action Unit Recognition: Aff-Wild2, Multi-Task Learning and ArcFace](https://mlsanity.com/paper/1910.04855/) (2019)
- [Deep Affect Prediction in-the-wild: Aff-Wild Database and Challenge, Deep Architectures, and Beyond](https://mlsanity.com/paper/1804.10938/) (2018)
- [Analysing Affective Behavior in the First ABAW 2020 Competition](https://mlsanity.com/paper/2001.11409/) (2020)
- [Affect Analysis in-the-wild: Valence-Arousal, Expressions, Action Units and a Unified Framework](https://mlsanity.com/paper/2103.15792/) (2021)
- [Distribution Matching for Heterogeneous Multi-Task Learning: a Large-scale Face Study](https://mlsanity.com/paper/2105.03790/) (2021)
- [Analysing Affective Behavior in the second ABAW2 Competition](https://mlsanity.com/paper/2106.15318/) (2021)
- [ABAW: Valence-Arousal Estimation, Expression Recognition, Action Unit Detection & Multi-Task Learning Challenges](https://mlsanity.com/paper/2202.10659/) (2022)
- [Face Behavior a la carte: Expressions, Affect and Action Units in a Single Network](https://mlsanity.com/paper/1910.11111/) (2019)
- [ABAW: Learning from Synthetic Data & Multi-Task Learning Challenges](https://mlsanity.com/paper/2207.01138/) (2022)
- [ABAW: Valence-Arousal Estimation, Expression Recognition, Action Unit Detection & Emotional Reaction Intensity Estimation Challenges](https://mlsanity.com/paper/2303.01498/) (2023)
- [Aff-Wild2: Extending the Aff-Wild Database for Affect Recognition](https://mlsanity.com/paper/1811.07770/) (2018)
- [Deep Transparent Prediction through Latent Representation Analysis](https://mlsanity.com/paper/2009.07044/) (2020)
- [MIA-COV19D: COVID-19 Detection through 3-D Chest CT Image Analysis](https://mlsanity.com/paper/2106.07524/) (2021)
- [Exploiting multi-CNN features in CNN-RNN based Dimensional Emotion Recognition on the OMG in-the-wild Dataset](https://mlsanity.com/paper/1910.01417/) (2019)
- [A Deep Neural Architecture for Harmonizing 3-D Input Data Analysis and Decision Making in Medical Imaging](https://mlsanity.com/paper/2303.00175/) (2023)
- [Photorealistic Facial Synthesis in the Dimensional Affect Space](https://mlsanity.com/paper/1811.08004/) (2018)
- [MixAugment & Mixup: Augmentation Methods for Facial Expression Recognition](https://mlsanity.com/paper/2205.04442/) (2022)
- [A Multi-Task Learning & Generation Framework: Valence-Arousal, Action Units & Primary Expressions](https://mlsanity.com/paper/1811.07771/) (2018)
- [Training Deep Neural Networks with Different Datasets In-the-wild: The Emotion Recognition Paradigm](https://mlsanity.com/paper/1809.04359/) (2018)
- [MMA-MRNNet: Harnessing Multiple Models of Affect and Dynamic Masked RNN for Precise Facial Expression Intensity Estimation](https://mlsanity.com/paper/2303.00180/) (2023)
- [A Multi-component CNN-RNN Approach for Dimensional Emotion Recognition in-the-wild](https://mlsanity.com/paper/1805.01452/) (2018)

## Built on by (most cited first, 20 of 20)

- [The 6th Affective Behavior Analysis in-the-wild (ABAW) Competition](https://mlsanity.com/paper/2402.19344/) (2024)
- [7th ABAW Competition: Multi-Task Learning and Compound Expression Recognition](https://mlsanity.com/paper/2407.03835/) (2024)
- [Domain adaptation, Explainability & Fairness in AI for Medical Image Analysis: Diagnosis of COVID-19 based on 3-D Chest CT-scans](https://mlsanity.com/paper/2403.02192/) (2024)
- [A review of deep learning-based information fusion techniques for multimodal medical image classification](https://mlsanity.com/paper/2404.15022/) (2024)
- [COVID-19 Computer-aided Diagnosis through AI-assisted CT Imaging Analysis: Deploying a Medical AI System](https://mlsanity.com/paper/2403.06242/) (2024)
- [Behaviour4All: in-the-wild Facial Behaviour Analysis Toolkit](https://mlsanity.com/paper/2409.17717/) (2024)
- [SAM2CLIP2SAM: Vision Language Model for Segmentation of 3D CT Scans for Covid-19 Detection](https://mlsanity.com/paper/2407.15728/) (2024)
- [DVD: A Comprehensive Dataset for Advancing Violence Detection in Real-World Scenarios](https://mlsanity.com/paper/2506.05372/) (2025)
- [Ensuring UAV Safety: A Vision-only and Real-time Framework for Collision Avoidance Through Object Detection, Tracking, and Distance Estimation](https://mlsanity.com/paper/2405.06749/) (2024)
- [Can Machine Learning Assist in Diagnosis of Primary Immune Thrombocytopenia? A feasibility study](https://mlsanity.com/paper/2405.20562/) (2024)
- [Rethinking Affect Analysis: A Protocol for Ensuring Fairness and Consistency](https://mlsanity.com/paper/2408.02164/) (2024)
- [Using Prompts to Guide Large Language Models in Imitating a Real Person's Language Style](https://mlsanity.com/paper/2410.03848/) (2024)
- [Robust Facial Reactions Generation: An Emotion-Aware Framework with Modality Compensation](https://mlsanity.com/paper/2407.15798/) (2024)
- [Common Corruptions for Enhancing and Evaluating Robustness in Air-to-Air Visual Object Detection](https://mlsanity.com/paper/2405.06765/) (2024)
- [Grounding Emotion Recognition with Visual Prototypes: VEGA -- Revisiting CLIP in MERC](https://mlsanity.com/paper/2508.06564/) (2025)
- [GANmut: Generating and Modifying Facial Expressions](https://mlsanity.com/paper/2406.11079/) (2024)
- [Multi-Task Learning for Affect Analysis](https://mlsanity.com/paper/2407.00679/) (2024)
- [Emotion Detection through Body Gesture and Face](https://mlsanity.com/paper/2407.09913/) (2024)
- [Unmasking unlearnable models: a classification challenge for biomedical images without visible cues](https://mlsanity.com/paper/2407.19773/) (2024)
- [Explainable Deep Radiogenomic Molecular Imaging for MGMT Methylation Prediction in Glioblastoma](https://mlsanity.com/paper/2601.07035/) (2026)

## Abstract (arXiv)

Brain tumors pose significant health challenges worldwide, with glioblastoma being one of the most aggressive forms. Accurate determination of the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is crucial for personalized treatment strategies. However, traditional methods are labor-intensive and time-consuming. This paper proposes a novel multi-modal approach, BTDNet, leveraging multi-parametric MRI scans, including FLAIR, T1w, T1wCE, and T2 3D volumes, to predict MGMT promoter methylation status. BTDNet addresses two main challenges: the variable volume lengths (i.e., each volume consists of a different number of slices) and the volume-level annotations (i.e., the whole 3D volume is annotated and not the independent slices that it consists of). BTDNet consists of four components: i) the data augmentation one (that performs geometric transformations, convex combinations of data pairs and test-time data augmentation); ii) the 3D analysis one (that performs global analysis through a CNN-RNN); iii) the routing one (that contains a mask layer that handles variable input feature lengths), and iv) the modality fusion one (that effectively enhances data representation, reduces ambiguities and mitigates data scarcity). The proposed method outperforms by large margins the state-of-the-art methods in the RSNA-ASNR-MICCAI BraTS 2021 Challenge, offering a promising avenue for enhancing brain tumor diagnosis and treatment.