# Conversational Health Agents: A Personalized LLM-Powered Agent Framework

arXiv: https://arxiv.org/abs/2310.02374 · HTML: https://mlsanity.com/paper/2310.02374/

## Key facts

- Cited by 92 papers in the map (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 19 of its 96 references that are in the map.
- First posted on arXiv 3 Oct 2023.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 19 of 19)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [Plan-and-Solve Prompting: Improving Zero-Shot Chain-of-Thought Reasoning by Large Language Models](https://mlsanity.com/paper/2305.04091/) (2023)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [Towards Generalist Biomedical AI](https://mlsanity.com/paper/2307.14334/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [Optimizing Prompts for Text-to-Image Generation](https://mlsanity.com/paper/2212.09611/) (2022)
- [MRKL Systems: A modular, neuro-symbolic architecture that combines large language models, external knowledge sources and discrete reasoning](https://mlsanity.com/paper/2205.00445/) (2022)
- [Hallucinations in Large Multilingual Translation Models](https://mlsanity.com/paper/2303.16104/) (2023)
- [Thinking about GPT-3 In-Context Learning for Biomedical IE? Think Again](https://mlsanity.com/paper/2203.08410/) (2022)
- [LLM-Rec: Personalized Recommendation via Prompting Large Language Models](https://mlsanity.com/paper/2307.15780/) (2023)
- [ELIXR: Towards a general purpose X-ray artificial intelligence system through alignment of large language models and radiology vision encoders](https://mlsanity.com/paper/2308.01317/) (2023)
- [Multimodal LLMs for health grounded in individual-specific data](https://mlsanity.com/paper/2307.09018/) (2023)
- [GPT-3 Models are Poor Few-Shot Learners in the Biomedical Domain](https://mlsanity.com/paper/2109.02555/) (2021)
- [Foundation Metrics for Evaluating Effectiveness of Healthcare Conversations Powered by Generative AI](https://mlsanity.com/paper/2309.12444/) (2023)
- [ZotCare: A Flexible, Personalizable, and Affordable mHealth Service Provider](https://mlsanity.com/paper/2307.01905/) (2023)

## Built on by (most cited first, 30 of 92)

- [AgentPoison: Red-teaming LLM Agents via Poisoning Memory or Knowledge Bases](https://mlsanity.com/paper/2407.12784/) (2024)
- [A Survey on Large Language Model (LLM) Security and Privacy: The Good, the Bad, and the Ugly](https://mlsanity.com/paper/2312.02003/) (2023)
- [Agent Security Bench (ASB): Formalizing and Benchmarking Attacks and Defenses in LLM-based Agents](https://mlsanity.com/paper/2410.02644/) (2024)
- [Personal LLM Agents: Insights and Survey about the Capability, Efficiency and Security](https://mlsanity.com/paper/2401.05459/) (2024)
- [From Persona to Personalization: A Survey on Role-Playing Language Agents](https://mlsanity.com/paper/2404.18231/) (2024)
- [AI Agents Under Threat: A Survey of Key Security Challenges and Future Pathways](https://mlsanity.com/paper/2406.02630/) (2024)
- [Adaptive Attacks Break Defenses Against Indirect Prompt Injection Attacks on LLM Agents](https://mlsanity.com/paper/2503.00061/) (2025)
- [GuardAgent: Safeguard LLM Agents by a Guard Agent via Knowledge-Enabled Reasoning](https://mlsanity.com/paper/2406.09187/) (2024)
- [Unveiling Privacy Risks in LLM Agent Memory](https://mlsanity.com/paper/2502.13172/) (2025)
- [From Matching to Generation: A Survey on Generative Information Retrieval](https://mlsanity.com/paper/2404.14851/) (2024)
- [AGrail: A Lifelong Agent Guardrail with Effective and Adaptive Safety Detection](https://mlsanity.com/paper/2502.11448/) (2025)
- [From Individual to Society: A Survey on Social Simulation Driven by Large Language Model-based Agents](https://mlsanity.com/paper/2412.03563/) (2024)
- [EHRAgent: Code Empowers Large Language Models for Few-shot Complex Tabular Reasoning on Electronic Health Records](https://mlsanity.com/paper/2401.07128/) (2024)
- [Agentic AI for Scientific Discovery: A Survey of Progress, Challenges, and Future Directions](https://mlsanity.com/paper/2503.08979/) (2025)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [Remember Me, Refine Me: A Dynamic Procedural Memory Framework for Experience-Driven Agent Evolution](https://mlsanity.com/paper/2512.10696/) (2025)
- [Instructional Segment Embedding: Improving LLM Safety with Instruction Hierarchy](https://mlsanity.com/paper/2410.09102/) (2024)
- [Safety at Scale: A Comprehensive Survey of Large Model and Agent Safety](https://mlsanity.com/paper/2502.05206/) (2025)
- [Retrieval Augmented Generation (RAG) and Beyond: A Comprehensive Survey on How to Make your LLMs use External Data More Wisely](https://mlsanity.com/paper/2409.14924/) (2024)
- [Large Language Models Empowered Personalized Web Agents](https://mlsanity.com/paper/2410.17236/) (2024)
- [LLM Agents for Education: Advances and Applications](https://mlsanity.com/paper/2503.11733/) (2025)
- [LLM-based Agents Suffer from Hallucinations: A Survey of Taxonomy, Methods, and Directions](https://mlsanity.com/paper/2509.18970/) (2025)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [ContextAgent: Context-Aware Proactive LLM Agents with Open-World Sensory Perceptions](https://mlsanity.com/paper/2505.14668/) (2025)
- [Personalized Large Language Models](https://mlsanity.com/paper/2402.09269/) (2024)
- [A Survey on Personalized Alignment -- The Missing Piece for Large Language Models in Real-World Applications](https://mlsanity.com/paper/2503.17003/) (2025)
- [HealthQ: Unveiling Questioning Capabilities of LLM Chains in Healthcare Conversations](https://mlsanity.com/paper/2409.19487/) (2024)
- [ALCM: Autonomous LLM-Augmented Causal Discovery Framework](https://mlsanity.com/paper/2405.01744/) (2024)
- [A Survey of Personalization: From RAG to Agent](https://mlsanity.com/paper/2504.10147/) (2025)
- [Attractive Metadata Attack: Inducing LLM Agents to Invoke Malicious Tools](https://mlsanity.com/paper/2508.02110/) (2025)

## Abstract (arXiv)

Conversational Health Agents (CHAs) are interactive systems that provide healthcare services, such as assistance and diagnosis. Current CHAs, especially those utilizing Large Language Models (LLMs), primarily focus on conversation aspects. However, they offer limited agent capabilities, specifically lacking multi-step problem-solving, personalized conversations, and multimodal data analysis. Our aim is to overcome these limitations. We propose openCHA, an open-source LLM-powered framework, to empower conversational agents to generate a personalized response for users' healthcare queries. This framework enables developers to integrate external sources including data sources, knowledge bases, and analysis models, into their LLM-based solutions. openCHA includes an orchestrator to plan and execute actions for gathering information from external sources, essential for formulating responses to user inquiries. It facilitates knowledge acquisition, problem-solving capabilities, multilingual and multimodal conversations, and fosters interaction with various AI platforms. We illustrate the framework's proficiency in handling complex healthcare tasks via two demonstrations and four use cases. Moreover, we release openCHA as open source available to the community via GitHub.