# A Comparative Study of Population-Graph Construction Methods and Graph Neural Networks for Brain Age Regression

arXiv: https://arxiv.org/abs/2309.14816 · HTML: https://mlsanity.com/paper/2309.14816/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 30 references that are in the map.
- First posted on arXiv 26 Sep 2023.

## Builds on (most cited first, 16 of 16)

- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Inductive Representation Learning on Large Graphs](https://mlsanity.com/paper/1706.02216/) (2017)
- [Fast Graph Representation Learning with PyTorch Geometric](https://mlsanity.com/paper/1903.02428/) (2019)
- [Convolutional Neural Networks on Graphs with Fast Localized Spectral Filtering](https://mlsanity.com/paper/1606.09375/) (2016)
- [Is Homophily a Necessity for Graph Neural Networks?](https://mlsanity.com/paper/2106.06134/) (2021)
- [Graph Neural Networks for Graphs with Heterophily: A Survey](https://mlsanity.com/paper/2202.07082/) (2022)
- [Disease Prediction using Graph Convolutional Networks: Application to Autism Spectrum Disorder and Alzheimer's Disease](https://mlsanity.com/paper/1806.01738/) (2018)
- [Differentiable Graph Module (DGM) for Graph Convolutional Networks](https://mlsanity.com/paper/2002.04999/) (2020)
- [Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker](https://mlsanity.com/paper/1612.02572/) (2016)
- [Graph-Based Deep Learning for Medical Diagnosis and Analysis: Past, Present and Future](https://mlsanity.com/paper/2105.13137/) (2021)
- [InceptionGCN: Receptive Field Aware Graph Convolutional Network for Disease Prediction](https://mlsanity.com/paper/1903.04233/) (2019)
- [Latent-Graph Learning for Disease Prediction](https://mlsanity.com/paper/2003.13620/) (2020)
- [Make Heterophily Graphs Better Fit GNN: A Graph Rewiring Approach](https://mlsanity.com/paper/2209.08264/) (2022)
- [Multimodal brain age estimation using interpretable adaptive population-graph learning](https://mlsanity.com/paper/2307.04639/) (2023)
- [Extended Graph Assessment Metrics for Graph Neural Networks](https://mlsanity.com/paper/2307.10112/) (2023)

## Built on by (most cited first, 2 of 2)

- [Exploiting Individual Graph Structures to Enhance Ecological Momentary Assessment (EMA) Forecasting](https://mlsanity.com/paper/2403.19442/) (2024)
- [Discovering robust biomarkers of psychiatric disorders from resting-state functional MRI via graph neural networks: A systematic review](https://mlsanity.com/paper/2405.00577/) (2024)

## Abstract (arXiv)

The difference between the chronological and biological brain age of a subject can be an important biomarker for neurodegenerative diseases, thus brain age estimation can be crucial in clinical settings. One way to incorporate multimodal information into this estimation is through population graphs, which combine various types of imaging data and capture the associations among individuals within a population. In medical imaging, population graphs have demonstrated promising results, mostly for classification tasks. In most cases, the graph structure is pre-defined and remains static during training. However, extracting population graphs is a non-trivial task and can significantly impact the performance of Graph Neural Networks (GNNs), which are sensitive to the graph structure. In this work, we highlight the importance of a meaningful graph construction and experiment with different population-graph construction methods and their effect on GNN performance on brain age estimation. We use the homophily metric and graph visualizations to gain valuable quantitative and qualitative insights on the extracted graph structures. For the experimental evaluation, we leverage the UK Biobank dataset, which offers many imaging and non-imaging phenotypes. Our results indicate that architectures highly sensitive to the graph structure, such as Graph Convolutional Network (GCN) and Graph Attention Network (GAT), struggle with low homophily graphs, while other architectures, such as GraphSage and Chebyshev, are more robust across different homophily ratios. We conclude that static graph construction approaches are potentially insufficient for the task of brain age estimation and make recommendations for alternative research directions.