# Large Language Models as Agents in the Clinic

arXiv: https://arxiv.org/abs/2309.10895 · HTML: https://mlsanity.com/paper/2309.10895/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 8 of its 25 references that are in the map.
- First posted on arXiv 19 Sep 2023.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 8 of 8)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [Sparks of Artificial General Intelligence: Early experiments with GPT-4](https://mlsanity.com/paper/2303.12712/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [Auto-GPT for Online Decision Making: Benchmarks and Additional Opinions](https://mlsanity.com/paper/2306.02224/) (2023)
- [Evaluation of GPT-3.5 and GPT-4 for supporting real-world information needs in healthcare delivery](https://mlsanity.com/paper/2304.13714/) (2023)

## Built on by (most cited first, 4 of 4)

- [The Minimum Information about CLinical Artificial Intelligence Checklist for Generative Modeling Research (MI-CLAIM-GEN)](https://mlsanity.com/paper/2403.02558/) (2024)
- [Investigating Tax Evasion Emergence Using Dual Large Language Model and Deep Reinforcement Learning Powered Agent-based Simulation](https://mlsanity.com/paper/2501.18177/) (2025)
- [ClinConsensus: A Physician-Calibrated Benchmark for Evaluating Clinical Rubric Coverage in Chinese Medical LLMs](https://mlsanity.com/paper/2603.02097/) (2026)
- [TumorBoard: Evidence-Grounded Multi-Agent Decision Support for Longitudinal Neuro-Oncology](https://mlsanity.com/paper/2608.03190/) (2026)

## Abstract (arXiv)

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as intelligent "agents" that interact with stakeholders in open-ended conversations and even influence clinical decision-making. Rather than relying on benchmarks that measure a model's ability to process clinical data or answer standardized test questions, LLM agents should be assessed for their performance on real-world clinical tasks. These new evaluation frameworks, which we call "Artificial-intelligence Structured Clinical Examinations" ("AI-SCI"), can draw from comparable technologies where machines operate with varying degrees of self-governance, such as self-driving cars. High-fidelity simulations may also be used to evaluate interactions between users and LLMs within a clinical workflow, or to model the dynamic interactions of multiple LLMs. Developing these robust, real-world clinical evaluations will be crucial towards deploying LLM agents into healthcare.