# CircleFormer: Circular Nuclei Detection in Whole Slide Images with Circle Queries and Attention

arXiv: https://arxiv.org/abs/2308.16145 · HTML: https://mlsanity.com/paper/2308.16145/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 19 references that are in the map.
- First posted on arXiv 30 Aug 2023.

## Builds on (most cited first, 16 of 16)

- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [Rich feature hierarchies for accurate object detection and semantic segmentation](https://mlsanity.com/paper/1311.2524/) (2013)
- [FCOS: Fully Convolutional One-Stage Object Detection](https://mlsanity.com/paper/1904.01355/) (2019)
- [Generalized Intersection over Union: A Metric and A Loss for Bounding Box Regression](https://mlsanity.com/paper/1902.09630/) (2019)
- [Objects as Points](https://mlsanity.com/paper/1904.07850/) (2019)
- [CornerNet: Detecting Objects as Paired Keypoints](https://mlsanity.com/paper/1808.01244/) (2018)
- [DAB-DETR: Dynamic Anchor Boxes are Better Queries for DETR](https://mlsanity.com/paper/2201.12329/) (2022)
- [Conditional DETR for Fast Training Convergence](https://mlsanity.com/paper/2108.06152/) (2021)
- [Fast Convergence of DETR with Spatially Modulated Co-Attention](https://mlsanity.com/paper/2101.07448/) (2021)
- [Instances as Queries](https://mlsanity.com/paper/2105.01928/) (2021)
- [CircleNet: Anchor-free Detection with Circle Representation](https://mlsanity.com/paper/2006.02474/) (2020)
- [SOIT: Segmenting Objects with Instance-Aware Transformers](https://mlsanity.com/paper/2112.11037/) (2021)

## Built on by (most cited first, 2 of 2)

- [Circle Representation for Medical Instance Object Segmentation](https://mlsanity.com/paper/2403.11507/) (2024)
- [A Survey on Cell Nuclei Instance Segmentation and Classification: Leveraging Context and Attention](https://mlsanity.com/paper/2407.18673/) (2024)

## Abstract (arXiv)

Both CNN-based and Transformer-based object detection with bounding box representation have been extensively studied in computer vision and medical image analysis, but circular object detection in medical images is still underexplored. Inspired by the recent anchor free CNN-based circular object detection method (CircleNet) for ball-shape glomeruli detection in renal pathology, in this paper, we present CircleFormer, a Transformer-based circular medical object detection with dynamic anchor circles. Specifically, queries with circle representation in Transformer decoder iteratively refine the circular object detection results, and a circle cross attention module is introduced to compute the similarity between circular queries and image features. A generalized circle IoU (gCIoU) is proposed to serve as a new regression loss of circular object detection as well. Moreover, our approach is easy to generalize to the segmentation task by adding a simple segmentation branch to CircleFormer. We evaluate our method in circular nuclei detection and segmentation on the public MoNuSeg dataset, and the experimental results show that our method achieves promising performance compared with the state-of-the-art approaches. The effectiveness of each component is validated via ablation studies as well. Our code is released at https://github.com/zhanghx-iim-ahu/CircleFormer.