# MammoDG: Generalisable Deep Learning Breaks the Limits of Cross-Domain Multi-Center Breast Cancer Screening

arXiv: https://arxiv.org/abs/2308.01057 · HTML: https://mlsanity.com/paper/2308.01057/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 43 references that are in the map.
- First posted on arXiv 2 Aug 2023.

## Builds on (most cited first, 16 of 16)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [FCOS: Fully Convolutional One-Stage Object Detection](https://mlsanity.com/paper/1904.01355/) (2019)
- [Domain Generalization: A Survey](https://mlsanity.com/paper/2103.02503/) (2021)
- [Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks](https://mlsanity.com/paper/1703.10593/) (2017)
- [Domain Generalization with MixStyle](https://mlsanity.com/paper/2104.02008/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [Hard Negative Mixing for Contrastive Learning](https://mlsanity.com/paper/2010.01028/) (2020)
- [Deep Neural Networks Improve Radiologists' Performance in Breast Cancer Screening](https://mlsanity.com/paper/1903.08297/) (2019)
- [End-to-end Training for Whole Image Breast Cancer Diagnosis using An All Convolutional Design](https://mlsanity.com/paper/1711.05775/) (2017)
- [An interpretable classifier for high-resolution breast cancer screening images utilizing weakly supervised localization](https://mlsanity.com/paper/2002.07613/) (2020)
- [Deep Multi-instance Networks with Sparse Label Assignment for Whole Mammogram Classification](https://mlsanity.com/paper/1612.05968/) (2016)
- [Robust breast cancer detection in mammography and digital breast tomosynthesis using annotation-efficient deep learning approach](https://mlsanity.com/paper/1912.11027/) (2019)
- [High-Resolution Breast Cancer Screening with Multi-View Deep Convolutional Neural Networks](https://mlsanity.com/paper/1703.07047/) (2017)
- [Domain Generalization for Mammography Detection via Multi-style and Multi-view Contrastive Learning](https://mlsanity.com/paper/2111.10827/) (2021)
- [Beyond Fine-tuning: Classifying High Resolution Mammograms using Function-Preserving Transformations](https://mlsanity.com/paper/2101.07945/) (2021)

## Built on by (most cited first, 7 of 7)

- [Semi-Supervised Video Desnowing Network via Temporal Decoupling Experts and Distribution-Driven Contrastive Regularization](https://mlsanity.com/paper/2410.07901/) (2024)
- [Diff-VPS: Video Polyp Segmentation via a Multi-task Diffusion Network with Adversarial Temporal Reasoning](https://mlsanity.com/paper/2409.07238/) (2024)
- [RetinaLogos: Fine-Grained Synthesis of High-Resolution Retinal Images Through Captions](https://mlsanity.com/paper/2505.12887/) (2025)
- [A Hybrid CNN-VSSM model for Multi-View, Multi-Task Mammography Analysis: Robust Diagnosis with Attention-Based Fusion](https://mlsanity.com/paper/2507.16955/) (2025)
- [HRVVS: A High-resolution Video Vasculature Segmentation Network via Hierarchical Autoregressive Residual Priors](https://mlsanity.com/paper/2507.22530/) (2025)
- [CECT-Mamba: a Hierarchical Contrast-enhanced-aware Model for Pancreatic Tumor Subtyping from Multi-phase CECT](https://mlsanity.com/paper/2509.12777/) (2025)
- [Learning Label-Efficient Interpretable Medical Image Diagnosis via Semi-supervised Hypergraph Concept Bottleneck Model](https://mlsanity.com/paper/2606.01698/) (2026)

## Abstract (arXiv)

Breast cancer is a major cause of cancer death among women, emphasising the importance of early detection for improved treatment outcomes and quality of life. Mammography, the primary diagnostic imaging test, poses challenges due to the high variability and patterns in mammograms. Double reading of mammograms is recommended in many screening programs to improve diagnostic accuracy but increases radiologists' workload. Researchers explore Machine Learning models to support expert decision-making. Stand-alone models have shown comparable or superior performance to radiologists, but some studies note decreased sensitivity with multiple datasets, indicating the need for high generalisation and robustness models. This work devises MammoDG, a novel deep-learning framework for generalisable and reliable analysis of cross-domain multi-center mammography data. MammoDG leverages multi-view mammograms and a novel contrastive mechanism to enhance generalisation capabilities. Extensive validation demonstrates MammoDG's superiority, highlighting the critical importance of domain generalisation for trustworthy mammography analysis in imaging protocol variations.