# Domain Adaptation for Medical Image Segmentation using Transformation-Invariant Self-Training

arXiv: https://arxiv.org/abs/2307.16660 · HTML: https://mlsanity.com/paper/2307.16660/

## Key facts

- Cited by 11 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 27 references that are in the map.
- First posted on arXiv 31 Jul 2023.

## Builds on (most cited first, 16 of 16)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [Temporal Ensembling for Semi-Supervised Learning](https://mlsanity.com/paper/1610.02242/) (2016)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [Contrastive learning of global and local features for medical image segmentation with limited annotations](https://mlsanity.com/paper/2006.10511/) (2020)
- [ST++: Make Self-training Work Better for Semi-supervised Semantic Segmentation](https://mlsanity.com/paper/2106.05095/) (2021)
- [Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/1903.00348/) (2019)
- [MS-Net: Multi-Site Network for Improving Prostate Segmentation with Heterogeneous MRI Data](https://mlsanity.com/paper/2002.03366/) (2020)
- [Unsupervised domain adaptation for medical imaging segmentation with self-ensembling](https://mlsanity.com/paper/1811.06042/) (2018)
- [Recalibrating Fully Convolutional Networks with Spatial and Channel 'Squeeze & Excitation' Blocks](https://mlsanity.com/paper/1808.08127/) (2018)
- [Test-time Unsupervised Domain Adaptation](https://mlsanity.com/paper/2010.01926/) (2020)
- [Relevance Detection in Cataract Surgery Videos by Spatio-Temporal Action Localization](https://mlsanity.com/paper/2104.14280/) (2021)
- [LensID: A CNN-RNN-Based Framework Towards Lens Irregularity Detection in Cataract Surgery Videos](https://mlsanity.com/paper/2107.00875/) (2021)
- [ReCal-Net: Joint Region-Channel-Wise Calibrated Network for Semantic Segmentation in Cataract Surgery Videos](https://mlsanity.com/paper/2109.12448/) (2021)
- [DeepPyramid: Enabling Pyramid View and Deformable Pyramid Reception for Semantic Segmentation in Cataract Surgery Videos](https://mlsanity.com/paper/2207.01453/) (2022)
- [Unsupervised Domain Adaptation with Contrastive Learning for OCT Segmentation](https://mlsanity.com/paper/2203.03664/) (2022)

## Built on by (most cited first, 11 of 11)

- [Cataract-1K: Cataract Surgery Dataset for Scene Segmentation, Phase Recognition, and Irregularity Detection](https://mlsanity.com/paper/2312.06295/) (2023)
- [SegSTRONG-C: Segmenting Surgical Tools Robustly On Non-adversarial Generated Corruptions -- An EndoVis'24 Challenge](https://mlsanity.com/paper/2407.11906/) (2024)
- [Navigating Distribution Shifts in Medical Image Analysis: A Survey](https://mlsanity.com/paper/2411.05824/) (2024)
- [SAM-DA: Decoder Adapter for Efficient Medical Domain Adaptation](https://mlsanity.com/paper/2501.06836/) (2025)
- [Domain Adaptation of Echocardiography Segmentation Via Reinforcement Learning](https://mlsanity.com/paper/2406.17902/) (2024)
- [Predicting Postoperative Intraocular Lens Dislocation in Cataract Surgery via Deep Learning](https://mlsanity.com/paper/2312.03401/) (2023)
- [Reinforcement Learning for Unsupervised Domain Adaptation in Spatio-Temporal Echocardiography Segmentation](https://mlsanity.com/paper/2510.14244/) (2025)
- [Contrastive-Adversarial and Diffusion: Exploring pre-training and fine-tuning strategies for sulcal identification](https://mlsanity.com/paper/2405.19204/) (2024)
- [WetCat: Enabling Automated Skill Assessment in Wet-Lab Cataract Surgery Videos](https://mlsanity.com/paper/2506.08896/) (2025)
- [SAM-Fed: SAM-Guided Federated Semi-Supervised Learning for Medical Image Segmentation](https://mlsanity.com/paper/2511.14302/) (2025)
- [DDS-UDA: Dual-Domain Synergy for Unsupervised Domain Adaptation in Joint Segmentation of Optic Disc and Optic Cup](https://mlsanity.com/paper/2603.13345/) (2026)

## Abstract (arXiv)

Models capable of leveraging unlabelled data are crucial in overcoming large distribution gaps between the acquired datasets across different imaging devices and configurations. In this regard, self-training techniques based on pseudo-labeling have been shown to be highly effective for semi-supervised domain adaptation. However, the unreliability of pseudo labels can hinder the capability of self-training techniques to induce abstract representation from the unlabeled target dataset, especially in the case of large distribution gaps. Since the neural network performance should be invariant to image transformations, we look to this fact to identify uncertain pseudo labels. Indeed, we argue that transformation invariant detections can provide more reasonable approximations of ground truth. Accordingly, we propose a semi-supervised learning strategy for domain adaptation termed transformation-invariant self-training (TI-ST). The proposed method assesses pixel-wise pseudo-labels' reliability and filters out unreliable detections during self-training. We perform comprehensive evaluations for domain adaptation using three different modalities of medical images, two different network architectures, and several alternative state-of-the-art domain adaptation methods. Experimental results confirm the superiority of our proposed method in mitigating the lack of target domain annotation and boosting segmentation performance in the target domain.