# Enhancing Super-Resolution Networks through Realistic Thick-Slice CT Simulation

arXiv: https://arxiv.org/abs/2307.10182 · HTML: https://mlsanity.com/paper/2307.10182/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 30 references that are in the map.
- First posted on arXiv 2 Jul 2023.

## Builds on (most cited first, 10 of 10)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [ESRGAN: Enhanced Super-Resolution Generative Adversarial Networks](https://mlsanity.com/paper/1809.00219/) (2018)
- [Accurate Image Super-Resolution Using Very Deep Convolutional Networks](https://mlsanity.com/paper/1511.04587/) (2015)
- [Activating More Pixels in Image Super-Resolution Transformer](https://mlsanity.com/paper/2205.04437/) (2022)
- [Fuzzy Attention Neural Network to Tackle Discontinuity in Airway Segmentation](https://mlsanity.com/paper/2209.02048/) (2022)
- [Multimodal Multi-Head Convolutional Attention with Various Kernel Sizes for Medical Image Super-Resolution](https://mlsanity.com/paper/2204.04218/) (2022)
- [Virtual Thin Slice: 3D Conditional GAN-based Super-resolution for CT Slice Interval](https://mlsanity.com/paper/1908.11506/) (2019)
- [You Don't Have to Be Perfect to Be Amazing: Unveil the Utility of Synthetic Images](https://mlsanity.com/paper/2305.18337/) (2023)
- [Is Autoencoder Truly Applicable for 3D CT Super-Resolution?](https://mlsanity.com/paper/2302.10272/) (2023)

## Abstract (arXiv)

Deep learning-based Generative Models have the potential to convert low-resolution CT images into high-resolution counterparts without long acquisition times and increased radiation exposure in thin-slice CT imaging. However, procuring appropriate training data for these Super-Resolution (SR) models is challenging. Previous SR research has simulated thick-slice CT images from thin-slice CT images to create training pairs. However, these methods either rely on simplistic interpolation techniques that lack realism or sinogram reconstruction, which require the release of raw data and complex reconstruction algorithms. Thus, we introduce a simple yet realistic method to generate thick CT images from thin-slice CT images, facilitating the creation of training pairs for SR algorithms. The training pairs produced by our method closely resemble real data distributions (PSNR=49.74 vs. 40.66, p<0.05). A multivariate Cox regression analysis involving thick slice CT images with lung fibrosis revealed that only the radiomics features extracted using our method demonstrated a significant correlation with mortality (HR=1.19 and HR=1.14, p<0.005). This paper represents the first to identify and address the challenge of generating appropriate paired training data for Deep Learning-based CT SR models, which enhances the efficacy and applicability of SR models in real-world scenarios.