# Challenges and Applications of Large Language Models

arXiv: https://arxiv.org/abs/2307.10169 · HTML: https://mlsanity.com/paper/2307.10169/

## Key facts

- Cited by 254 papers in the map (data through 14 Oct 2026).
- Builds on 290 of its 686 references that are in the map.
- First posted on arXiv 19 Jul 2023.

## Builds on (most cited first, 30 of 290)

- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness](https://mlsanity.com/paper/2205.14135/) (2022)
- [Program Synthesis with Large Language Models](https://mlsanity.com/paper/2108.07732/) (2021)
- [Outrageously Large Neural Networks: The Sparsely-Gated Mixture-of-Experts Layer](https://mlsanity.com/paper/1701.06538/) (2017)
- [Lost in the Middle: How Language Models Use Long Contexts](https://mlsanity.com/paper/2307.03172/) (2023)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Tree of Thoughts: Deliberate Problem Solving with Large Language Models](https://mlsanity.com/paper/2305.10601/) (2023)
- [Constitutional AI: Harmlessness from AI Feedback](https://mlsanity.com/paper/2212.08073/) (2022)
- [TruthfulQA: Measuring How Models Mimic Human Falsehoods](https://mlsanity.com/paper/2109.07958/) (2021)
- [Neural Machine Translation of Rare Words with Subword Units](https://mlsanity.com/paper/1508.07909/) (2015)
- [A Survey of Large Language Models](https://mlsanity.com/paper/2303.18223/) (2023)
- [The Pile: An 800GB Dataset of Diverse Text for Language Modeling](https://mlsanity.com/paper/2101.00027/) (2020)
- [Do As I Can, Not As I Say: Grounding Language in Robotic Affordances](https://mlsanity.com/paper/2204.01691/) (2022)
- [Voyager: An Open-Ended Embodied Agent with Large Language Models](https://mlsanity.com/paper/2305.16291/) (2023)
- [Fine-Tuning Language Models from Human Preferences](https://mlsanity.com/paper/1909.08593/) (2019)
- [PaLM-E: An Embodied Multimodal Language Model](https://mlsanity.com/paper/2303.03378/) (2023)
- [Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models](https://mlsanity.com/paper/2206.04615/) (2022)
- [SentencePiece: A simple and language independent subword tokenizer and detokenizer for Neural Text Processing](https://mlsanity.com/paper/1808.06226/) (2018)
- [GPTQ: Accurate Post-Training Quantization for Generative Pre-trained Transformers](https://mlsanity.com/paper/2210.17323/) (2022)
- [Megatron-LM: Training Multi-Billion Parameter Language Models Using Model Parallelism](https://mlsanity.com/paper/1909.08053/) (2019)
- [Challenging BIG-Bench Tasks and Whether Chain-of-Thought Can Solve Them](https://mlsanity.com/paper/2210.09261/) (2022)
- [Improving Factuality and Reasoning in Language Models through Multiagent Debate](https://mlsanity.com/paper/2305.14325/) (2023)

## Built on by (most cited first, 30 of 254)

- [Math-Shepherd: Verify and Reinforce LLMs Step-by-step without Human Annotations](https://mlsanity.com/paper/2312.08935/) (2023)
- [Siren's Song in the AI Ocean: A Survey on Hallucination in Large Language Models](https://mlsanity.com/paper/2309.01219/) (2023)
- [Large Language Models: A Survey](https://mlsanity.com/paper/2402.06196/) (2024)
- [AndroidWorld: A Dynamic Benchmarking Environment for Autonomous Agents](https://mlsanity.com/paper/2405.14573/) (2024)
- [StruQ: Defending Against Prompt Injection with Structured Queries](https://mlsanity.com/paper/2402.06363/) (2024)
- [Are We Done with MMLU?](https://mlsanity.com/paper/2406.04127/) (2024)
- [Efficient Large Language Models: A Survey](https://mlsanity.com/paper/2312.03863/) (2023)
- [Security and Privacy Challenges of Large Language Models: A Survey](https://mlsanity.com/paper/2402.00888/) (2024)
- [A Comprehensive Study of Knowledge Editing for Large Language Models](https://mlsanity.com/paper/2401.01286/) (2024)
- [Open Sesame! Universal Black Box Jailbreaking of Large Language Models](https://mlsanity.com/paper/2309.01446/) (2023)
- [REASONING GYM: Reasoning Environments for Reinforcement Learning with Verifiable Rewards](https://mlsanity.com/paper/2505.24760/) (2025)
- [Benchmarking LLMs via Uncertainty Quantification](https://mlsanity.com/paper/2401.12794/) (2024)
- [MLGym: A New Framework and Benchmark for Advancing AI Research Agents](https://mlsanity.com/paper/2502.14499/) (2025)
- [AutoSurvey: Large Language Models Can Automatically Write Surveys](https://mlsanity.com/paper/2406.10252/) (2024)
- [A Comprehensive Survey in LLM(-Agent) Full Stack Safety: Data, Training and Deployment](https://mlsanity.com/paper/2504.15585/) (2025)
- [ClashEval: Quantifying the tug-of-war between an LLM's internal prior and external evidence](https://mlsanity.com/paper/2404.10198/) (2024)
- [A Survey on Large Language Model-Based Game Agents](https://mlsanity.com/paper/2404.02039/) (2024)
- [Jatmo: Prompt Injection Defense by Task-Specific Finetuning](https://mlsanity.com/paper/2312.17673/) (2023)
- [Faithfulness vs. Plausibility: On the (Un)Reliability of Explanations from Large Language Models](https://mlsanity.com/paper/2402.04614/) (2024)
- [On-Device Language Models: A Comprehensive Review](https://mlsanity.com/paper/2409.00088/) (2024)
- [ARGS: Alignment as Reward-Guided Search](https://mlsanity.com/paper/2402.01694/) (2024)
- [Large Language Models Meet NLP: A Survey](https://mlsanity.com/paper/2405.12819/) (2024)
- [EasyEdit: An Easy-to-use Knowledge Editing Framework for Large Language Models](https://mlsanity.com/paper/2308.07269/) (2023)
- [Large Language Models for Robotics: Opportunities, Challenges, and Perspectives](https://mlsanity.com/paper/2401.04334/) (2024)
- [Use of LLMs for Illicit Purposes: Threats, Prevention Measures, and Vulnerabilities](https://mlsanity.com/paper/2308.12833/) (2023)
- [KV Cache is 1 Bit Per Channel: Efficient Large Language Model Inference with Coupled Quantization](https://mlsanity.com/paper/2405.03917/) (2024)
- [Alignment for Honesty](https://mlsanity.com/paper/2312.07000/) (2023)
- [Unleashing the potential of prompt engineering for large language models](https://mlsanity.com/paper/2310.14735/) (2023)
- [SafeVLA: Towards Safety Alignment of Vision-Language-Action Model via Constrained Learning](https://mlsanity.com/paper/2503.03480/) (2025)
- [Rejection Improves Reliability: Training LLMs to Refuse Unknown Questions Using RL from Knowledge Feedback](https://mlsanity.com/paper/2403.18349/) (2024)

## Abstract (arXiv)

Large Language Models (LLMs) went from non-existent to ubiquitous in the machine learning discourse within a few years. Due to the fast pace of the field, it is difficult to identify the remaining challenges and already fruitful application areas. In this paper, we aim to establish a systematic set of open problems and application successes so that ML researchers can comprehend the field's current state more quickly and become productive.