# Systematic comparison of semi-supervised and self-supervised learning for medical image classification

arXiv: https://arxiv.org/abs/2307.08919 · HTML: https://mlsanity.com/paper/2307.08919/

## Key facts

- Cited by 8 papers in the map (data through 14 Oct 2026).
- Builds on 54 of its 89 references that are in the map.
- First posted on arXiv 18 Jul 2023.

## Builds on (most cited first, 30 of 54)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [Wide Residual Networks](https://mlsanity.com/paper/1605.07146/) (2016)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [Improved Baselines with Momentum Contrastive Learning](https://mlsanity.com/paper/2003.04297/) (2020)
- [RandAugment: Practical automated data augmentation with a reduced search space](https://mlsanity.com/paper/1909.13719/) (2019)
- [FixMatch: Simplifying Semi-Supervised Learning with Consistency and Confidence](https://mlsanity.com/paper/2001.07685/) (2020)
- [Barlow Twins: Self-Supervised Learning via Redundancy Reduction](https://mlsanity.com/paper/2103.03230/) (2021)
- [MixMatch: A Holistic Approach to Semi-Supervised Learning](https://mlsanity.com/paper/1905.02249/) (2019)
- [Big Self-Supervised Models are Strong Semi-Supervised Learners](https://mlsanity.com/paper/2006.10029/) (2020)
- [A Comprehensive Survey on Transfer Learning](https://mlsanity.com/paper/1911.02685/) (2019)
- [Temporal Ensembling for Semi-Supervised Learning](https://mlsanity.com/paper/1610.02242/) (2016)
- [Deep Clustering for Unsupervised Learning of Visual Features](https://mlsanity.com/paper/1807.05520/) (2018)
- [MedMNIST v2 -- A large-scale lightweight benchmark for 2D and 3D biomedical image classification](https://mlsanity.com/paper/2110.14795/) (2021)
- [Self-supervised Visual Feature Learning with Deep Neural Networks: A Survey](https://mlsanity.com/paper/1902.06162/) (2019)
- [FlexMatch: Boosting Semi-Supervised Learning with Curriculum Pseudo Labeling](https://mlsanity.com/paper/2110.08263/) (2021)
- [Semi-Supervised Learning with Deep Generative Models](https://mlsanity.com/paper/1406.5298/) (2014)
- [Transfusion: Understanding Transfer Learning for Medical Imaging](https://mlsanity.com/paper/1902.07208/) (2019)
- [S4L: Self-Supervised Semi-Supervised Learning](https://mlsanity.com/paper/1905.03670/) (2019)

## Built on by (most cited first, 8 of 8)

- [FluenceFormer: Transformer-Driven Multi-Beam Fluence Map Regression for Radiotherapy Planning](https://mlsanity.com/paper/2512.22425/) (2025)
- [Evaluating Self-Supervised Learning in Medical Imaging: A Benchmark for Robustness, Generalizability, and Multi-Domain Impact](https://mlsanity.com/paper/2412.19124/) (2024)
- [SSL-SE-EEG: A Framework for Robust Learning from Unlabeled EEG Data with Self-Supervised Learning and Squeeze-Excitation Networks](https://mlsanity.com/paper/2510.19829/) (2025)
- [A Multi-Dataset Benchmark of Multiple Instance Learning for 3D Neuroimage Classification](https://mlsanity.com/paper/2604.26807/) (2026)
- [Exploring learning environments for label-efficient cancer diagnosis](https://mlsanity.com/paper/2408.07988/) (2024)
- [ConceptVAE: Self-Supervised Fine-Grained Concept Disentanglement from 2D Echocardiographies](https://mlsanity.com/paper/2502.01335/) (2025)
- [Subgroup Validity in Machine Learning for Echocardiogram Data](https://mlsanity.com/paper/2512.00976/) (2025)
- [Domain-Specific Self-Supervised Representation Learning for Retinal Fundus Classification](https://mlsanity.com/paper/2608.26686/) (2026)

## Abstract (arXiv)

In typical medical image classification problems, labeled data is scarce while unlabeled data is more available. Semi-supervised learning and self-supervised learning are two different research directions that can improve accuracy by learning from extra unlabeled data. Recent methods from both directions have reported significant gains on traditional benchmarks. Yet past benchmarks do not focus on medical tasks and rarely compare self- and semi- methods together on an equal footing. Furthermore, past benchmarks often handle hyperparameter tuning suboptimally. First, they may not tune hyperparameters at all, leading to underfitting. Second, when tuning does occur, it often unrealistically uses a labeled validation set that is much larger than the training set. Therefore currently published rankings might not always corroborate with their practical utility This study contributes a systematic evaluation of self- and semi- methods with a unified experimental protocol intended to guide a practitioner with scarce overall labeled data and a limited compute budget. We answer two key questions: Can hyperparameter tuning be effective with realistic-sized validation sets? If so, when all methods are tuned well, which self- or semi-supervised methods achieve the best accuracy? Our study compares 13 representative semi- and self-supervised methods to strong labeled-set-only baselines on 4 medical datasets. From 20000+ GPU hours of computation, we provide valuable best practices to resource-constrained practitioners: hyperparameter tuning is effective, and the semi-supervised method known as MixMatch delivers the most reliable gains across 4 datasets.