# Improving Segmentation and Detection of Lesions in CT Scans Using Intensity Distribution Supervision

arXiv: https://arxiv.org/abs/2307.05804 · HTML: https://mlsanity.com/paper/2307.05804/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 40 references that are in the map.
- First posted on arXiv 11 Jul 2023.

## Builds on (most cited first, 13 of 13)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Feature Pyramid Networks for Object Detection](https://mlsanity.com/paper/1612.03144/) (2016)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Generalised Dice overlap as a deep learning loss function for highly unbalanced segmentations](https://mlsanity.com/paper/1707.03237/) (2017)
- [The state of the art in kidney and kidney tumor segmentation in contrast-enhanced CT imaging: Results of the KiTS19 Challenge](https://mlsanity.com/paper/1912.01054/) (2019)
- [Retina U-Net: Embarrassingly Simple Exploitation of Segmentation Supervision for Medical Object Detection](https://mlsanity.com/paper/1811.08661/) (2018)
- [LNDb: A Lung Nodule Database on Computed Tomography](https://mlsanity.com/paper/1911.08434/) (2019)
- [Cascaded V-Net using ROI masks for brain tumor segmentation](https://mlsanity.com/paper/1812.11588/) (2018)
- [Deep Lesion Tracker: Monitoring Lesions in 4D Longitudinal Imaging Studies](https://mlsanity.com/paper/2012.04872/) (2020)
- [Joint Weakly and Semi-Supervised Deep Learning for Localization and Classification of Masses in Breast Ultrasound Images](https://mlsanity.com/paper/1710.03778/) (2017)
- [E2Net: An Edge Enhanced Network for Accurate Liver and Tumor Segmentation on CT Scans](https://mlsanity.com/paper/2007.09791/) (2020)
- [Improving Small Lesion Segmentation in CT Scans using Intensity Distribution Supervision: Application to Small Bowel Carcinoid Tumor](https://mlsanity.com/paper/2207.14700/) (2022)

## Built on by (most cited first, 2 of 2)

- [Embracing Intra-Class Heterogeneity for Semi-Supervised Medical Image Segmentation: From Diversity to Precision](https://mlsanity.com/paper/2607.02051/) (2026)
- [CT-PrepAgent: Bounded Policy and Controlled Execution for Adaptive CT Data Preparation](https://mlsanity.com/paper/2608.01233/) (2026)

## Abstract (arXiv)

We propose a method to incorporate the intensity information of a target lesion on CT scans in training segmentation and detection networks. We first build an intensity-based lesion probability (ILP) function from an intensity histogram of the target lesion. It is used to compute the probability of being the lesion for each voxel based on its intensity. Finally, the computed ILP map of each input CT scan is provided as additional supervision for network training, which aims to inform the network about possible lesion locations in terms of intensity values at no additional labeling cost. The method was applied to improve the segmentation of three different lesion types, namely, small bowel carcinoid tumor, kidney tumor, and lung nodule. The effectiveness of the proposed method on a detection task was also investigated. We observed improvements of 41.3% -> 47.8%, 74.2% -> 76.0%, and 26.4% -> 32.7% in segmenting small bowel carcinoid tumor, kidney tumor, and lung nodule, respectively, in terms of per case Dice scores. An improvement of 64.6% -> 75.5% was achieved in detecting kidney tumors in terms of average precision. The results of different usages of the ILP map and the effect of varied amount of training data are also presented.