# OpenAPMax: Abnormal Patterns-based Model for Real-World Alzheimer's Disease Diagnosis

arXiv: https://arxiv.org/abs/2307.00936 · HTML: https://mlsanity.com/paper/2307.00936/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 52 references that are in the map.
- First posted on arXiv 3 Jul 2023.

## Builds on (most cited first, 14 of 14)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Generative Adversarial Networks: An Overview](https://mlsanity.com/paper/1710.07035/) (2017)
- [Towards Open Set Deep Networks](https://mlsanity.com/paper/1511.06233/) (2015)
- [Recent Advances in Open Set Recognition: A Survey](https://mlsanity.com/paper/1811.08581/) (2018)
- [Classification-Reconstruction Learning for Open-Set Recognition](https://mlsanity.com/paper/1812.04246/) (2018)
- [C2AE: Class Conditioned Auto-Encoder for Open-set Recognition](https://mlsanity.com/paper/1904.01198/) (2019)
- [OpenGAN: Open-Set Recognition via Open Data Generation](https://mlsanity.com/paper/2104.02939/) (2021)
- [Evidential Deep Learning for Open Set Action Recognition](https://mlsanity.com/paper/2107.10161/) (2021)
- [Residual and Plain Convolutional Neural Networks for 3D Brain MRI Classification](https://mlsanity.com/paper/1701.06643/) (2017)
- [Learning a Neural-network-based Representation for Open Set Recognition](https://mlsanity.com/paper/1802.04365/) (2018)
- [Transfer Learning with intelligent training data selection for prediction of Alzheimer's Disease](https://mlsanity.com/paper/1906.01160/) (2019)
- [Collective Decision of One-vs-Rest Networks for Open Set Recognition](https://mlsanity.com/paper/2103.10230/) (2021)
- [Dynamic Image for 3D MRI Image Alzheimer's Disease Classification](https://mlsanity.com/paper/2012.00119/) (2020)

## Abstract (arXiv)

Alzheimer's disease (AD) cannot be reversed, but early diagnosis will significantly benefit patients' medical treatment and care. In recent works, AD diagnosis has the primary assumption that all categories are known a prior -- a closed-set classification problem, which contrasts with the open-set recognition problem. This assumption hinders the application of the model in natural clinical settings. Although many open-set recognition technologies have been proposed in other fields, they are challenging to use for AD diagnosis directly since 1) AD is a degenerative disease of the nervous system with similar symptoms at each stage, and it is difficult to distinguish from its pre-state, and 2) diversified strategies for AD diagnosis are challenging to model uniformly. In this work, inspired by the concerns of clinicians during diagnosis, we propose an open-set recognition model, OpenAPMax, based on the anomaly pattern to address AD diagnosis in real-world settings. OpenAPMax first obtains the abnormal pattern of each patient relative to each known category through statistics or a literature search, clusters the patients' abnormal pattern, and finally, uses extreme value theory (EVT) to model the distance between each patient's abnormal pattern and the center of their category and modify the classification probability. We evaluate the performance of the proposed method with recent open-set recognition, where we obtain state-of-the-art results.