# Leveraging GPT-4 for Food Effect Summarization to Enhance Product-Specific Guidance Development via Iterative Prompting

arXiv: https://arxiv.org/abs/2306.16275 · HTML: https://mlsanity.com/paper/2306.16275/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 28 of its 45 references that are in the map.
- First posted on arXiv 28 Jun 2023.

## Builds on (most cited first, 28 of 28)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [BART: Denoising Sequence-to-Sequence Pre-training for Natural Language Generation, Translation, and Comprehension](https://mlsanity.com/paper/1910.13461/) (2019)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedback](https://mlsanity.com/paper/2204.05862/) (2022)
- [Tree of Thoughts: Deliberate Problem Solving with Large Language Models](https://mlsanity.com/paper/2305.10601/) (2023)
- [Sequence to Sequence Learning with Neural Networks](https://mlsanity.com/paper/1409.3215/) (2014)
- [Pre-train, Prompt, and Predict: A Systematic Survey of Prompting Methods in Natural Language Processing](https://mlsanity.com/paper/2107.13586/) (2021)
- [Get To The Point: Summarization with Pointer-Generator Networks](https://mlsanity.com/paper/1704.04368/) (2017)
- [PEGASUS: Pre-training with Extracted Gap-sentences for Abstractive Summarization](https://mlsanity.com/paper/1912.08777/) (2019)
- [How Can We Know What Language Models Know?](https://mlsanity.com/paper/1911.12543/) (2019)
- [Exploiting Cloze Questions for Few Shot Text Classification and Natural Language Inference](https://mlsanity.com/paper/2001.07676/) (2020)
- [Abstractive Text Summarization Using Sequence-to-Sequence RNNs and Beyond](https://mlsanity.com/paper/1602.06023/) (2016)
- [SummEval: Re-evaluating Summarization Evaluation](https://mlsanity.com/paper/2007.12626/) (2020)
- [Benchmarking Large Language Models for News Summarization](https://mlsanity.com/paper/2301.13848/) (2023)
- [News Summarization and Evaluation in the Era of GPT-3](https://mlsanity.com/paper/2209.12356/) (2022)
- [ChatIE: Zero-Shot Information Extraction via Chatting with ChatGPT](https://mlsanity.com/paper/2302.10205/) (2023)
- [SummaRuNNer: A Recurrent Neural Network based Sequence Model for Extractive Summarization of Documents](https://mlsanity.com/paper/1611.04230/) (2016)
- [Incorporating Copying Mechanism in Sequence-to-Sequence Learning](https://mlsanity.com/paper/1603.06393/) (2016)
- [BRIO: Bringing Order to Abstractive Summarization](https://mlsanity.com/paper/2203.16804/) (2022)
- [Progressive-Hint Prompting Improves Reasoning in Large Language Models](https://mlsanity.com/paper/2304.09797/) (2023)
- [Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics](https://mlsanity.com/paper/2304.01938/) (2023)
- [Re-Examining System-Level Correlations of Automatic Summarization Evaluation Metrics](https://mlsanity.com/paper/2204.10216/) (2022)
- [Clinical Prompt Learning with Frozen Language Models](https://mlsanity.com/paper/2205.05535/) (2022)
- [Fine-Tuning BERT for Automatic ADME Semantic Labeling in FDA Drug Labeling to Enhance Product-Specific Guidance Assessment](https://mlsanity.com/paper/2207.12376/) (2022)

## Built on by (most cited first, 2 of 2)

- [Improving Faithfulness of Large Language Models in Summarization via Sliding Generation and Self-Consistency](https://mlsanity.com/paper/2407.21443/) (2024)
- [Extracting chemical food safety hazards from the scientific literature automatically using large language models](https://mlsanity.com/paper/2405.15787/) (2024)

## Abstract (arXiv)

Food effect summarization from New Drug Application (NDA) is an essential component of product-specific guidance (PSG) development and assessment. However, manual summarization of food effect from extensive drug application review documents is time-consuming, which arouses a need to develop automated methods. Recent advances in large language models (LLMs) such as ChatGPT and GPT-4, have demonstrated great potential in improving the effectiveness of automated text summarization, but its ability regarding the accuracy in summarizing food effect for PSG assessment remains unclear. In this study, we introduce a simple yet effective approach, iterative prompting, which allows one to interact with ChatGPT or GPT-4 more effectively and efficiently through multi-turn interaction. Specifically, we propose a three-turn iterative prompting approach to food effect summarization in which the keyword-focused and length-controlled prompts are respectively provided in consecutive turns to refine the quality of the generated summary. We conduct a series of extensive evaluations, ranging from automated metrics to FDA professionals and even evaluation by GPT-4, on 100 NDA review documents selected over the past five years. We observe that the summary quality is progressively improved throughout the process. Moreover, we find that GPT-4 performs better than ChatGPT, as evaluated by FDA professionals (43% vs. 12%) and GPT-4 (64% vs. 35%). Importantly, all the FDA professionals unanimously rated that 85% of the summaries generated by GPT-4 are factually consistent with the golden reference summary, a finding further supported by GPT-4 rating of 72% consistency. These results strongly suggest a great potential for GPT-4 to draft food effect summaries that could be reviewed by FDA professionals, thereby improving the efficiency of PSG assessment cycle and promoting the generic drug product development.