# A Machine Learning Approach for Predicting Deterioration in Alzheimer's Disease

arXiv: https://arxiv.org/abs/2306.10334 · HTML: https://mlsanity.com/paper/2306.10334/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 0 of its 13 references that are in the map.
- First posted on arXiv 17 Jun 2023.

## Built on by (most cited first, 1 of 1)

- [Predicting Deterioration in Mild Cognitive Impairment with Survival Transformers, Extreme Gradient Boosting and Cox Proportional Hazard Modelling](https://mlsanity.com/paper/2409.16231/) (2024)

## Abstract (arXiv)

This paper explores deterioration in Alzheimers Disease using Machine Learning. Subjects were split into two datasets based on baseline diagnosis (Cognitively Normal, Mild Cognitive Impairment), with outcome of deterioration at final visit (a binomial essentially yes/no categorisation) using data from the Alzheimers Disease Neuroimaging Initiative (demographics, genetics, CSF, imaging, and neuropsychological testing etc). Six machine learning models, including gradient boosting, were built, and evaluated on these datasets using a nested crossvalidation procedure, with the best performing models being put through repeated nested cross-validation at 100 iterations. We were able to demonstrate good predictive ability using CART predicting which of those in the cognitively normal group deteriorated and received a worse diagnosis (AUC = 0.88). For the mild cognitive impairment group, we were able to achieve good predictive ability for deterioration with Elastic Net (AUC = 0.76).