# ClinicalGPT: Large Language Models Finetuned with Diverse Medical Data and Comprehensive Evaluation

arXiv: https://arxiv.org/abs/2306.09968 · HTML: https://mlsanity.com/paper/2306.09968/

## Key facts

- Cited by 88 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 27 references that are in the map.
- First posted on arXiv 16 Jun 2023.

## Builds on (most cited first, 14 of 14)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Learning to summarize from human feedback](https://mlsanity.com/paper/2009.01325/) (2020)
- [BLOOM: A 176B-Parameter Open-Access Multilingual Language Model](https://mlsanity.com/paper/2211.05100/) (2022)
- [WebGPT: Browser-assisted question-answering with human feedback](https://mlsanity.com/paper/2112.09332/) (2021)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [LaMDA: Language Models for Dialog Applications](https://mlsanity.com/paper/2201.08239/) (2022)
- [Aligning Books and Movies: Towards Story-like Visual Explanations by Watching Movies and Reading Books](https://mlsanity.com/paper/1506.06724/) (2015)
- [GLM-130B: An Open Bilingual Pre-trained Model](https://mlsanity.com/paper/2210.02414/) (2022)

## Built on by (most cited first, 30 of 88)

- [BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains](https://mlsanity.com/paper/2402.10373/) (2024)
- [MetaTool Benchmark for Large Language Models: Deciding Whether to Use Tools and Which to Use](https://mlsanity.com/paper/2310.03128/) (2023)
- [Aya Dataset: An Open-Access Collection for Multilingual Instruction Tuning](https://mlsanity.com/paper/2402.06619/) (2024)
- [A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics](https://mlsanity.com/paper/2310.05694/) (2023)
- [Large language models in healthcare and medical domain: A review](https://mlsanity.com/paper/2401.06775/) (2023)
- [A Survey of Large Language Models in Medicine: Progress, Application, and Challenge](https://mlsanity.com/paper/2311.05112/) (2023)
- [Should we be going MAD? A Look at Multi-Agent Debate Strategies for LLMs](https://mlsanity.com/paper/2311.17371/) (2023)
- [Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions](https://mlsanity.com/paper/2402.18060/) (2024)
- [A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine](https://mlsanity.com/paper/2405.08603/) (2024)
- [MedExpQA: Multilingual Benchmarking of Large Language Models for Medical Question Answering](https://mlsanity.com/paper/2404.05590/) (2024)
- [Improving Medical Large Vision-Language Models with Abnormal-Aware Feedback](https://mlsanity.com/paper/2501.01377/) (2025)
- [Large Language Models for Medicine: A Survey](https://mlsanity.com/paper/2405.13055/) (2024)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [Taiyi: A Bilingual Fine-Tuned Large Language Model for Diverse Biomedical Tasks](https://mlsanity.com/paper/2311.11608/) (2023)
- [A Survey on Medical Large Language Models: Technology, Application, Trustworthiness, and Future Directions](https://mlsanity.com/paper/2406.03712/) (2024)
- [OphCLIP: Hierarchical Retrieval-Augmented Learning for Ophthalmic Surgical Video-Language Pretraining](https://mlsanity.com/paper/2411.15421/) (2024)
- [ChatHome: Development and Evaluation of a Domain-Specific Language Model for Home Renovation](https://mlsanity.com/paper/2307.15290/) (2023)
- [AI-TA: Towards an Intelligent Question-Answer Teaching Assistant using Open-Source LLMs](https://mlsanity.com/paper/2311.02775/) (2023)
- [Multilingual Large Language Models: A Systematic Survey](https://mlsanity.com/paper/2411.11072/) (2024)
- [Leveraging Biomolecule and Natural Language through Multi-Modal Learning: A Survey](https://mlsanity.com/paper/2403.01528/) (2024)
- [Large Language Model Benchmarks in Medical Tasks](https://mlsanity.com/paper/2410.21348/) (2024)
- [A Survey on Large Language Models from General Purpose to Medical Applications: Datasets, Methodologies, and Evaluations](https://mlsanity.com/paper/2406.10303/) (2024)
- [Multimodal Large Language Models for Medicine: A Comprehensive Survey](https://mlsanity.com/paper/2504.21051/) (2025)
- [Medical mT5: An Open-Source Multilingual Text-to-Text LLM for The Medical Domain](https://mlsanity.com/paper/2404.07613/) (2024)
- [Large Language Models in the Clinic: A Comprehensive Benchmark](https://mlsanity.com/paper/2405.00716/) (2024)
- [Open Challenges and Opportunities in Federated Foundation Models Towards Biomedical Healthcare](https://mlsanity.com/paper/2405.06784/) (2024)
- [StockGPT: A GenAI Model for Stock Prediction and Trading](https://mlsanity.com/paper/2404.05101/) (2024)
- [Autonomous Agents for Scientific Discovery: Orchestrating Scientists, Language, Code, and Physics](https://mlsanity.com/paper/2510.09901/) (2025)
- [MedGUIDE: Benchmarking Clinical Decision-Making in Large Language Models](https://mlsanity.com/paper/2505.11613/) (2025)
- [Integrating Physician Diagnostic Logic into Large Language Models: Preference Learning from Process Feedback](https://mlsanity.com/paper/2401.05695/) (2024)

## Abstract (arXiv)

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in medical applications is limited, due to challenges such as factual inaccuracies, reasoning abilities, and lack grounding in real-world experience. In this study, we present ClinicalGPT, a language model explicitly designed and optimized for clinical scenarios. By incorporating extensive and diverse real-world data, such as medical records, domain-specific knowledge, and multi-round dialogue consultations in the training process, ClinicalGPT is better prepared to handle multiple clinical task. Furthermore, we introduce a comprehensive evaluation framework that includes medical knowledge question-answering, medical exams, patient consultations, and diagnostic analysis of medical records. Our results demonstrate that ClinicalGPT significantly outperforms other models in these tasks, highlighting the effectiveness of our approach in adapting large language models to the critical domain of healthcare.