# UOD: Universal One-shot Detection of Anatomical Landmarks

arXiv: https://arxiv.org/abs/2306.07615 · HTML: https://mlsanity.com/paper/2306.07615/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 27 references that are in the map.
- First posted on arXiv 13 Jun 2023.

## Builds on (most cited first, 15 of 15)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Going deeper with Image Transformers](https://mlsanity.com/paper/2103.17239/) (2021)
- [A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises](https://mlsanity.com/paper/2008.09104/) (2020)
- [Data augmentation using learned transformations for one-shot medical image segmentation](https://mlsanity.com/paper/1902.09383/) (2019)
- [Integrating Spatial Configuration into Heatmap Regression Based CNNs for Landmark Localization](https://mlsanity.com/paper/1908.00748/) (2019)
- [3FabRec: Fast Few-shot Face alignment by Reconstruction](https://mlsanity.com/paper/1911.10448/) (2019)
- [One-Shot Medical Landmark Detection](https://mlsanity.com/paper/2103.04527/) (2021)
- [You Only Learn Once: Universal Anatomical Landmark Detection](https://mlsanity.com/paper/2103.04657/) (2021)
- [Miss the Point: Targeted Adversarial Attack on Multiple Landmark Detection](https://mlsanity.com/paper/2007.05225/) (2020)
- [Which images to label for few-shot medical landmark detection?](https://mlsanity.com/paper/2112.04386/) (2021)
- [BiometryNet: Landmark-based Fetal Biometry Estimation from Standard Ultrasound Planes](https://mlsanity.com/paper/2206.14678/) (2022)
- [Accurate Scoliosis Vertebral Landmark Localization on X-ray Images via Shape-constrained Multi-stage Cascaded CNNs](https://mlsanity.com/paper/2206.02087/) (2022)

## Built on by (most cited first, 9 of 9)

- [Revisiting Cephalometric Landmark Detection from the view of Human Pose Estimation with Lightweight Super-Resolution Head](https://mlsanity.com/paper/2309.17143/) (2023)
- [FM-OSD: Foundation Model-Enabled One-Shot Detection of Anatomical Landmarks](https://mlsanity.com/paper/2407.05412/) (2024)
- [Self-supervised pre-training with diffusion model for few-shot landmark detection in x-ray images](https://mlsanity.com/paper/2407.18125/) (2024)
- [CABLD: Contrast-Agnostic Brain Landmark Detection with Consistency-Based Regularization](https://mlsanity.com/paper/2411.17845/) (2024)
- [Towards Better Cephalometric Landmark Detection with Diffusion Data Generation](https://mlsanity.com/paper/2505.06055/) (2025)
- [Reliability of deep learning models for anatomical landmark detection: The role of inter-rater variability](https://mlsanity.com/paper/2411.17850/) (2024)
- [MedSapiens: Taking a Pose to Rethink Medical Imaging Landmark Detection](https://mlsanity.com/paper/2511.04255/) (2025)
- [Focus on Background: Exploring SAM's Potential in Few-shot Medical Image Segmentation with Background-centric Prompting](https://mlsanity.com/paper/2603.21287/) (2026)
- [Landmarks Are Alike Yet Distinct: Harnessing Similarity and Individuality for One-Shot Medical Landmark Detection](https://mlsanity.com/paper/2503.16058/) (2025)

## Abstract (arXiv)

One-shot medical landmark detection gains much attention and achieves great success for its label-efficient training process. However, existing one-shot learning methods are highly specialized in a single domain and suffer domain preference heavily in the situation of multi-domain unlabeled data. Moreover, one-shot learning is not robust that it faces performance drop when annotating a sub-optimal image. To tackle these issues, we resort to developing a domain-adaptive one-shot landmark detection framework for handling multi-domain medical images, named Universal One-shot Detection (UOD). UOD consists of two stages and two corresponding universal models which are designed as combinations of domain-specific modules and domain-shared modules. In the first stage, a domain-adaptive convolution model is self-supervised learned to generate pseudo landmark labels. In the second stage, we design a domain-adaptive transformer to eliminate domain preference and build the global context for multi-domain data. Even though only one annotated sample from each domain is available for training, the domain-shared modules help UOD aggregate all one-shot samples to detect more robust and accurate landmarks. We investigated both qualitatively and quantitatively the proposed UOD on three widely-used public X-ray datasets in different anatomical domains (i.e., head, hand, chest) and obtained state-of-the-art performances in each domain. The code is available at https://github.com/heqin-zhu/UOD_universal_oneshot_detection.