# Utilizing ChatGPT to Enhance Clinical Trial Enrollment

arXiv: https://arxiv.org/abs/2306.02077 · HTML: https://mlsanity.com/paper/2306.02077/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 55 of its 108 references that are in the map.
- First posted on arXiv 3 Jun 2023.

## Builds on (most cited first, 30 of 55)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [A Survey of Large Language Models](https://mlsanity.com/paper/2303.18223/) (2023)
- [Pre-train, Prompt, and Predict: A Systematic Survey of Prompting Methods in Natural Language Processing](https://mlsanity.com/paper/2107.13586/) (2021)
- [Survey of Hallucination in Natural Language Generation](https://mlsanity.com/paper/2202.03629/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [Least-to-Most Prompting Enables Complex Reasoning in Large Language Models](https://mlsanity.com/paper/2205.10625/) (2022)
- [Calibrate Before Use: Improving Few-Shot Performance of Language Models](https://mlsanity.com/paper/2102.09690/) (2021)
- [Scaling Language Models: Methods, Analysis & Insights from Training Gopher](https://mlsanity.com/paper/2112.11446/) (2021)
- [What Makes Good In-Context Examples for GPT-3?](https://mlsanity.com/paper/2101.06804/) (2021)
- [Fantastically Ordered Prompts and Where to Find Them: Overcoming Few-Shot Prompt Order Sensitivity](https://mlsanity.com/paper/2104.08786/) (2021)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [A Multitask, Multilingual, Multimodal Evaluation of ChatGPT on Reasoning, Hallucination, and Interactivity](https://mlsanity.com/paper/2302.04023/) (2023)
- [Show Your Work: Scratchpads for Intermediate Computation with Language Models](https://mlsanity.com/paper/2112.00114/) (2021)
- [CTRL: A Conditional Transformer Language Model for Controllable Generation](https://mlsanity.com/paper/1909.05858/) (2019)
- [Learning To Retrieve Prompts for In-Context Learning](https://mlsanity.com/paper/2112.08633/) (2021)
- [Prompt Programming for Large Language Models: Beyond the Few-Shot Paradigm](https://mlsanity.com/paper/2102.07350/) (2021)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)

## Built on by (most cited first, 4 of 4)

- [Matching Patients to Clinical Trials with Large Language Models](https://mlsanity.com/paper/2307.15051/) (2023)
- [Investigating Task Arithmetic for Zero-Shot Information Retrieval](https://mlsanity.com/paper/2505.00649/) (2025)
- [Controlled LLM-based Reasoning for Clinical Trial Retrieval](https://mlsanity.com/paper/2409.18998/) (2024)
- [A systematic review of trial-matching pipelines using large language models](https://mlsanity.com/paper/2509.19327/) (2025)

## Abstract (arXiv)

Clinical trials are a critical component of evaluating the effectiveness of new medical interventions and driving advancements in medical research. Therefore, timely enrollment of patients is crucial to prevent delays or premature termination of trials. In this context, Electronic Health Records (EHRs) have emerged as a valuable tool for identifying and enrolling eligible participants. In this study, we propose an automated approach that leverages ChatGPT, a large language model, to extract patient-related information from unstructured clinical notes and generate search queries for retrieving potentially eligible clinical trials. Our empirical evaluation, conducted on two benchmark retrieval collections, shows improved retrieval performance compared to existing approaches when several general-purposed and task-specific prompts are used. Notably, ChatGPT-generated queries also outperform human-generated queries in terms of retrieval performance. These findings highlight the potential use of ChatGPT to enhance clinical trial enrollment while ensuring the quality of medical service and minimizing direct risks to patients.