# Reconstructing the Mind's Eye: fMRI-to-Image with Contrastive Learning and Diffusion Priors

arXiv: https://arxiv.org/abs/2305.18274 · HTML: https://mlsanity.com/paper/2305.18274/

## Key facts

- Cited by 160 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 45 of its 81 references that are in the map.
- First posted on arXiv 29 May 2023.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 45)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [SDEdit: Guided Image Synthesis and Editing with Stochastic Differential Equations](https://mlsanity.com/paper/2108.01073/) (2021)
- [Enhanced Deep Residual Networks for Single Image Super-Resolution](https://mlsanity.com/paper/1707.02921/) (2017)
- [VICReg: Variance-Invariance-Covariance Regularization for Self-Supervised Learning](https://mlsanity.com/paper/2105.04906/) (2021)
- [Improved Techniques for Training Score-Based Generative Models](https://mlsanity.com/paper/2006.09011/) (2020)
- [AugMix: A Simple Data Processing Method to Improve Robustness and Uncertainty](https://mlsanity.com/paper/1912.02781/) (2019)
- [AutoAugment: Learning Augmentation Policies from Data](https://mlsanity.com/paper/1805.09501/) (2018)
- [Network Dissection: Quantifying Interpretability of Deep Visual Representations](https://mlsanity.com/paper/1704.05796/) (2017)
- [Vector-quantized Image Modeling with Improved VQGAN](https://mlsanity.com/paper/2110.04627/) (2021)
- [LiT: Zero-Shot Transfer with Locked-image text Tuning](https://mlsanity.com/paper/2111.07991/) (2021)
- [Mind the Gap: Understanding the Modality Gap in Multi-modal Contrastive Representation Learning](https://mlsanity.com/paper/2203.02053/) (2022)
- [StyleGAN-XL: Scaling StyleGAN to Large Diverse Datasets](https://mlsanity.com/paper/2202.00273/) (2022)
- [UniPC: A Unified Predictor-Corrector Framework for Fast Sampling of Diffusion Models](https://mlsanity.com/paper/2302.04867/) (2023)

## Built on by (most cited first, 30 of 160)

- [OneLLM: One Framework to Align All Modalities with Language](https://mlsanity.com/paper/2312.03700/) (2023)
- [MindEye2: Shared-Subject Models Enable fMRI-To-Image With 1 Hour of Data](https://mlsanity.com/paper/2403.11207/) (2024)
- [Visual Decoding and Reconstruction via EEG Embeddings with Guided Diffusion](https://mlsanity.com/paper/2403.07721/) (2024)
- [Brain decoding: toward real-time reconstruction of visual perception](https://mlsanity.com/paper/2310.19812/) (2023)
- [MindBridge: A Cross-Subject Brain Decoding Framework](https://mlsanity.com/paper/2404.07850/) (2024)
- [DREAM: Visual Decoding from Reversing Human Visual System](https://mlsanity.com/paper/2310.02265/) (2023)
- [NeuroPictor: Refining fMRI-to-Image Reconstruction via Multi-individual Pretraining and Multi-level Modulation](https://mlsanity.com/paper/2403.18211/) (2024)
- [UMBRAE: Unified Multimodal Brain Decoding](https://mlsanity.com/paper/2404.07202/) (2024)
- [Bridging the Vision-Brain Gap with an Uncertainty-Aware Blur Prior](https://mlsanity.com/paper/2503.04207/) (2025)
- [CognitionCapturer: Decoding Visual Stimuli From Human EEG Signal With Multimodal Information](https://mlsanity.com/paper/2412.10489/) (2024)
- [NeuroClips: Towards High-fidelity and Smooth fMRI-to-Video Reconstruction](https://mlsanity.com/paper/2410.19452/) (2024)
- [Improving visual image reconstruction from human brain activity using latent diffusion models via multiple decoded inputs](https://mlsanity.com/paper/2306.11536/) (2023)
- [Neuro-3D: Towards 3D Visual Decoding from EEG Signals](https://mlsanity.com/paper/2411.12248/) (2024)
- [Psychometry: An Omnifit Model for Image Reconstruction from Human Brain Activity](https://mlsanity.com/paper/2403.20022/) (2024)
- [Scaling laws for decoding images from brain activity](https://mlsanity.com/paper/2501.15322/) (2025)
- [Deep Neural Networks and Brain Alignment: Brain Encoding and Decoding (Survey)](https://mlsanity.com/paper/2307.10246/) (2023)
- [Through their eyes: multi-subject Brain Decoding with simple alignment techniques](https://mlsanity.com/paper/2309.00627/) (2023)
- [Brain-Conditional Multimodal Synthesis: A Survey and Taxonomy](https://mlsanity.com/paper/2401.00430/) (2023)
- [The Wisdom of a Crowd of Brains: A Universal Brain Encoder](https://mlsanity.com/paper/2406.12179/) (2024)
- [MindSimulator: Exploring Brain Concept Localization via Synthetic FMRI](https://mlsanity.com/paper/2503.02351/) (2025)
- [Towards a general-purpose foundation model for fMRI analysis](https://mlsanity.com/paper/2506.11167/) (2025)
- [MindLLM: A Subject-Agnostic and Versatile Model for fMRI-to-Text Decoding](https://mlsanity.com/paper/2502.15786/) (2025)
- [NeuroBridge: Bio-Inspired Self-Supervised EEG-to-Image Decoding via Cognitive Priors and Bidirectional Semantic Alignment](https://mlsanity.com/paper/2511.06836/) (2025)
- [NeuroBind: Towards Unified Multimodal Representations for Neural Signals](https://mlsanity.com/paper/2407.14020/) (2024)
- [MinD-3D: Reconstruct High-quality 3D objects in Human Brain](https://mlsanity.com/paper/2312.07485/) (2023)
- [Animate Your Thoughts: Decoupled Reconstruction of Dynamic Natural Vision from Slow Brain Activity](https://mlsanity.com/paper/2405.03280/) (2024)
- [CineBrain: A Large-Scale Multi-Modal Brain Dataset During Naturalistic Audiovisual Narrative Processing](https://mlsanity.com/paper/2503.06940/) (2025)
- [Aligning brain functions boosts the decoding of visual semantics in novel subjects](https://mlsanity.com/paper/2312.06467/) (2023)
- [NECOMIMI: Neural-Cognitive Multimodal EEG-informed Image Generation with Diffusion Models](https://mlsanity.com/paper/2410.00712/) (2024)
- [Open-vocabulary Auditory Neural Decoding Using fMRI-prompted LLM](https://mlsanity.com/paper/2405.07840/) (2024)

## Abstract (arXiv)

We present MindEye, a novel fMRI-to-image approach to retrieve and reconstruct viewed images from brain activity. Our model comprises two parallel submodules that are specialized for retrieval (using contrastive learning) and reconstruction (using a diffusion prior). MindEye can map fMRI brain activity to any high dimensional multimodal latent space, like CLIP image space, enabling image reconstruction using generative models that accept embeddings from this latent space. We comprehensively compare our approach with other existing methods, using both qualitative side-by-side comparisons and quantitative evaluations, and show that MindEye achieves state-of-the-art performance in both reconstruction and retrieval tasks. In particular, MindEye can retrieve the exact original image even among highly similar candidates indicating that its brain embeddings retain fine-grained image-specific information. This allows us to accurately retrieve images even from large-scale databases like LAION-5B. We demonstrate through ablations that MindEye's performance improvements over previous methods result from specialized submodules for retrieval and reconstruction, improved training techniques, and training models with orders of magnitude more parameters. Furthermore, we show that MindEye can better preserve low-level image features in the reconstructions by using img2img, with outputs from a separate autoencoder. All code is available on GitHub.