# Automated discovery of interpretable hyperelastic material models for human brain tissue with EUCLID

arXiv: https://arxiv.org/abs/2305.16362 · HTML: https://mlsanity.com/paper/2305.16362/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 25 May 2023.

## Built on by (most cited first, 10 of 10)

- [A review on data-driven constitutive laws for solids](https://mlsanity.com/paper/2405.03658/) (2024)
- [Extreme sparsification of physics-augmented neural networks for interpretable model discovery in mechanics](https://mlsanity.com/paper/2310.03652/) (2023)
- [Can KAN CANs? Input-convex Kolmogorov-Arnold Networks (KANs) as hyperelastic constitutive artificial neural networks (CANs)](https://mlsanity.com/paper/2503.05617/) (2025)
- [Polyconvex Physics-Augmented Neural Network Constitutive Models in Principal Stretches](https://mlsanity.com/paper/2503.00575/) (2025)
- [A Complement to Neural Networks for Anisotropic Inelasticity at Finite Strains](https://mlsanity.com/paper/2510.04187/) (2025)
- [Generalized invariants meet constitutive neural networks: A novel framework for hyperelastic materials](https://mlsanity.com/paper/2508.12063/) (2025)
- [Automated Constitutive Model Discovery by Pairing Sparse Regression Algorithms with Model Selection Criteria](https://mlsanity.com/paper/2509.16040/) (2025)
- [Hyperelastic constitutive model discovery with differentiable finite elements and structure-preserving neural networks](https://mlsanity.com/paper/2603.26517/) (2026)
- [CANN-EUCLID: unsupervised constitutive artificial neural network model discovery from full-field data](https://mlsanity.com/paper/2606.14565/) (2026)
- [Benchmarking data-driven material models on the classic Treloar dataset](https://mlsanity.com/paper/2608.14063/) (2026)

## Abstract (arXiv)

We propose an automated computational algorithm for simultaneous model selection and parameter identification for the hyperelastic mechanical characterization of human brain tissue. Following the motive of the recently proposed computational framework EUCLID (Efficient Unsupervised Constitutive Law Identitication and Discovery) and in contrast to conventional parameter calibration methods, we construct an extensive set of candidate hyperelastic models, i.e., a model library including popular models known from the literature, and develop a computational strategy for automatically selecting a model from the library that conforms to the available experimental data while being represented as an interpretable symbolic mathematical expression. This computational strategy comprises sparse regression, i.e., a regression problem that is regularized by a sparsity promoting penalty term that filters out irrelevant models from the model library, and a clustering method for grouping together highly correlated and thus redundant features in the model library. The model selection procedure is driven by labelled data pairs stemming from mechanical tests under different deformation modes, i.e., uniaxial compression/tension and simple torsion, and can thus be interpreted as a supervised counterpart to the originally proposed EUCLID that is informed by full-field displacement data and global reaction forces. The proposed method is verified on synthetical data with artificial noise and validated on experimental data acquired through mechanical tests of human brain specimens, proving that the method is capable of discovering hyperelastic models that exhibit both high fitting accuracy to the data as well as concise and thus interpretable mathematical representations.