# Incomplete Multimodal Learning for Complex Brain Disorders Prediction

arXiv: https://arxiv.org/abs/2305.16222 · HTML: https://mlsanity.com/paper/2305.16222/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 28 references that are in the map.
- First posted on arXiv 25 May 2023.

## Builds on (most cited first, 14 of 14)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [XGBoost: A Scalable Tree Boosting System](https://mlsanity.com/paper/1603.02754/) (2016)
- [Revisiting Deep Learning Models for Tabular Data](https://mlsanity.com/paper/2106.11959/) (2021)
- [TabNet: Attentive Interpretable Tabular Learning](https://mlsanity.com/paper/1908.07442/) (2019)
- [Deep Mutual Learning](https://mlsanity.com/paper/1706.00384/) (2017)
- [Self-Normalizing Neural Networks](https://mlsanity.com/paper/1706.02515/) (2017)
- [The relativistic discriminator: a key element missing from standard GAN](https://mlsanity.com/paper/1807.00734/) (2018)
- [Neural Oblivious Decision Ensembles for Deep Learning on Tabular Data](https://mlsanity.com/paper/1909.06312/) (2019)
- [What Makes Multi-modal Learning Better than Single (Provably)](https://mlsanity.com/paper/2106.04538/) (2021)
- [Gradient Boosting Neural Networks: GrowNet](https://mlsanity.com/paper/2002.07971/) (2020)
- [TCGM: An Information-Theoretic Framework for Semi-Supervised Multi-Modality Learning](https://mlsanity.com/paper/2007.06793/) (2020)
- [CircleGAN: Generative Adversarial Learning across Spherical Circles](https://mlsanity.com/paper/2011.12486/) (2020)

## Built on by (most cited first, 1 of 1)

- [A Systematic Review on the Generative AI Applications in Human Medical Genomics](https://mlsanity.com/paper/2508.20275/) (2025)

## Abstract (arXiv)

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches typically need a complete set of biomedical data modalities, which may not always be feasible, as some modalities are only available in large-scale research cohorts and are prohibitive to collect in routine clinical practice. Especially in studies of brain diseases, research cohorts may include both neuroimaging data and genetic data, but for practical clinical diagnosis, we often need to make disease predictions only based on neuroimages. As a result, it is desired to design machine learning models which can use all available data (different data could provide complementary information) during training but conduct inference using only the most common data modality. We propose a new incomplete multimodal data integration approach that employs transformers and generative adversarial networks to effectively exploit auxiliary modalities available during training in order to improve the performance of a unimodal model at inference. We apply our new method to predict cognitive degeneration and disease outcomes using the multimodal imaging genetic data from Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Experimental results demonstrate that our approach outperforms the related machine learning and deep learning methods by a significant margin.